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应用德国S2k脊椎椎间盘炎诊断和治疗指南——对无神经症状患者的5年回顾性评估

Applying the German S2k-Guideline for Diagnosis and Treatment of Spondylodiscitis-A 5-Year Retrospective Evaluation of Patients without Neurological Symptoms.

作者信息

Kolster Moritz, Hönning Alexander, Käckenmester Wiebke, Goy Janet, Ekkernkamp Axel, Spranger Nikolai

机构信息

Department of Trauma and Orthopaedic Surgery, BG Klinikum Unfallkrankenhaus Berlin gGmbH, 12683 Berlin, Germany.

Centre for Clinical Research, BG Klinikum Unfallkrankenhaus Berlin gGmbH, 12683 Berlin, Germany.

出版信息

Diagnostics (Basel). 2024 May 25;14(11):1098. doi: 10.3390/diagnostics14111098.

Abstract

Spondylodiscitis is a rather rare condition with an annual incidence of 1-7 per 100,000. Thus, empirical data on the treatment of this disease are limited. In 2020, the first German guideline for the diagnosis and treatment of spondylodiscitis was published. In a 5-year retrospective analysis, we examined the patient collective, the current diagnosis and treatment strategy, and the effect of Magnetic Resonance Imaging (MRI) diagnostics on therapeutic decisions of a consecutive monocentric cohort of 66 patients without neurological symptoms. The majority of the patients were male (55%) with a mean age of 74 years. Non-operative therapy was found to be associated with short-term treatment success in 54 (82%) of the patients. In 12 patients, who underwent surgical therapy, MRI diagnostics and clinical findings were equally important for the decision to perform a surgery. Patients treated operatively stayed for an average of 33.6 (±12.9) days in the hospital and thus significantly longer than non-operatively treated patients with 22.2 (±8.0) days. The in-house standard of care did not essentially deviate from the guideline's recommendations. Future research should address early detection of the need for surgical therapy, and immediate anti-infective treatment appropriate to the detected pathogen.

摘要

脊椎椎间盘炎是一种相当罕见的疾病,年发病率为每10万人中有1 - 7例。因此,关于这种疾病治疗的经验数据有限。2020年,德国发布了首个脊椎椎间盘炎诊断和治疗指南。在一项为期5年的回顾性分析中,我们研究了一组连续的、无神经症状的66例单中心队列患者的情况、当前的诊断和治疗策略,以及磁共振成像(MRI)诊断对治疗决策的影响。大多数患者为男性(55%),平均年龄74岁。发现54例(82%)患者的非手术治疗与短期治疗成功相关。在12例接受手术治疗的患者中,MRI诊断和临床发现对手术决策同样重要。接受手术治疗的患者平均住院33.6(±12.9)天,因此明显长于非手术治疗患者的22.2(±8.0)天。内部护理标准与指南建议基本没有偏差。未来的研究应关注手术治疗需求的早期检测,以及针对检测到的病原体进行及时的抗感染治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d302/11172179/6cbe6d354af4/diagnostics-14-01098-g001.jpg

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