Argyropoulos Georgios D, Christidi Foteini, Karavasilis Efstratios, Bede Peter, Velonakis Georgios, Antoniou Anastasia, Seimenis Ioannis, Kelekis Nikolaos, Smyrnis Nikolaos, Papakonstantinou Olympia, Efstathopoulos Efstathios, Ferentinos Panagiotis
Research Unit of Radiology and Medical Imaging, 2nd Department of Radiology, Attikon General University Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece.
2nd Department of Psychiatry, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece.
Diagnostics (Basel). 2024 May 31;14(11):1170. doi: 10.3390/diagnostics14111170.
Although magnetic resonance spectroscopy (MRS) has provided in vivo measurements of brain chemical profiles in bipolar disorder (BD), there are no data on clinically and therapeutically important onset polarity (OP) and predominant polarity (PP). We conducted a proton MRS study in BD polarity subphenotypes, focusing on emotion regulation brain regions. Forty-one euthymic BD patients stratified according to OP and PP and sixteen healthy controls (HC) were compared. 1H-MRS spectra of the anterior and posterior cingulate cortex (ACC, PCC), left and right hippocampus (LHIPPO, RHIPPO) were acquired at 3.0T to determine metabolite concentrations. We found significant main effects of OP in ACC mI, mI/tNAA, mI/tCr, mI/tCho, PCC tCho, and RHIPPO tNAA/tCho and tCho/tCr. Although PP had no significant main effects, several medium and large effect sizes emerged. Compared to HC, manic subphenotypes (i.e., manic-OP, manic-PP) showed greater differences in RHIPPO and PCC, whereas depressive suphenotypes (i.e., depressive-OP, depressive-PP) in ACC. Effect sizes were consistent between OP and PP as high intraclass correlation coefficients (ICC) were confirmed. Our findings support the utility of MRS in the study of the neurobiological underpinnings of OP and PP, highlighting that the regional specificity of metabolite changes within the emotion regulation network consistently marks both polarity subphenotypes.
尽管磁共振波谱（MRS）已用于双相情感障碍（BD）患者脑化学特征的体内测量，但尚无关于临床和治疗上重要的起病极性（OP）和优势极性（PP）的数据。我们针对BD极性亚表型开展了一项质子MRS研究，重点关注情绪调节脑区。比较了根据OP和PP分层的41例心境正常的BD患者和16名健康对照者（HC）。在3.0T条件下采集前扣带回皮质（ACC）、后扣带回皮质（PCC）、左侧和右侧海马体（LHIPPO、RHIPPO）的1H-MRS波谱，以测定代谢物浓度。我们发现，OP在ACC的肌醇（mI）、mI/总N-乙酰天门冬氨酸（tNAA）、mI/磷酸肌酸（tCr）、mI/胆碱（tCho），PCC的tCho以及RHIPPO的tNAA/tCho和tCho/tCr方面有显著的主效应。尽管PP没有显著的主效应，但出现了几个中效应和大效应量。与HC相比，躁狂亚表型（即躁狂-OP、躁狂-PP）在RHIPPO和PCC中表现出更大差异，而抑郁亚表型（即抑郁-OP、抑郁-PP）在ACC中表现出更大差异。由于证实了高组内相关系数（ICC），OP和PP之间的效应量是一致的。我们的研究结果支持MRS在研究OP和PP的神经生物学基础方面的效用，强调情绪调节网络内代谢物变化的区域特异性始终标志着两种极性亚表型。
