Goya Luis, Mateos Raquel
Department of Metabolism and Nutrition, Institute of Food Science, Technology, and Nutrition (ICTAN-CSIC), Spanish National Research Council (CSIC), 28040 Madrid, Spain.
Nutr Rev. 2025 Mar 1;83(3):e1225-e1242. doi: 10.1093/nutrit/nuae066.
Following the goal of optimizing nutrition, the food industry has been continuously working on food reformulation, nutritional patterns, functional foods development, and the general promotion of a healthy lifestyle. To this end, the scientific community has been increasingly investigating natural compounds that could prevent or treat chronic diseases. Phlorotannins and bromophenols are phenolic compounds particularly present in marine organisms. There is extensive evidence that shows their potential in the prevention of noncommunicable diseases, including cancer, the second cause of mortality worldwide. Numerous studies have demonstrated the anticarcinogenic activity of polyphenolic algae compounds both in cell culture and experimental animal models. Although recent reviews are also available, the present update focuses on the most recent findings related to the antioxidant/anti-inflammatory effect of seaweed phenolics, as well as their regulatory capacity for new molecular targets. Additionally, the review addresses and discusses the close link between inflammation and oxidative stress, along with their relationship with tumor onset and progression, including the most recent findings supporting this correlation. Although clinical studies are still needed to support this evidence, phlorotannins and bromophenols constitute an emerging bioactive group with high potential as chemopreventive agents and/or potential adjuvants for existing cancer therapies.
为了实现优化营养的目标，食品行业一直在持续致力于食品配方改良、营养模式研究、功能性食品开发以及全面推广健康的生活方式。为此，科学界越来越多地研究能够预防或治疗慢性疾病的天然化合物。间苯三酚单宁和溴酚是特别存在于海洋生物中的酚类化合物。有大量证据表明它们在预防包括癌症（全球第二大致死原因）在内的非传染性疾病方面具有潜力。众多研究已经在细胞培养和实验动物模型中证明了多酚类藻类化合物的抗癌活性。尽管近期也有相关综述，但本更新聚焦于与海藻酚类物质的抗氧化/抗炎作用以及它们对新分子靶点的调节能力相关的最新研究结果。此外，该综述阐述并讨论了炎症与氧化应激之间的紧密联系，以及它们与肿瘤发生和进展的关系，包括支持这种相关性的最新研究结果。尽管仍需要临床研究来支持这一证据，但间苯三酚单宁和溴酚构成了一个具有高潜力的新兴生物活性基团，可作为化学预防剂和/或现有癌症治疗的潜在佐剂。
