Osuka Akinori, Shigeno Ayami, Matsuura Hiroshi, Onishi Shinya, Yoneda Kazuhiro
Department of Trauma, Critical Care Medicine and Burn Center Japan Community Health Care Organization Chukyo Hospital Nagoya Japan.
Department of Traumatology and Acute Critical Medicine Osaka University Graduate School of Medicine Osaka Japan.
Acute Med Surg. 2024 Jun 18;11(1):e976. doi: 10.1002/ams2.976. eCollection 2024 Jan-Dec.
Immune responses that occur following burn injury comprise a series of reactions that are activated in response to damaged autologous tissues, followed by removal of damaged tissues and foreign pathogens such as invading bacteria, and tissue repair. These immune responses are considered to be programmed in living organisms. Developments of modern medicine have led to the saving of burned patients who could not be cured previously; however, the programmed response is no longer able to keep up, and various problems have arisen. This paper describes the mechanism of immune response specific to burn injury and the emerging concept of persistent inflammation, immunosuppression, and catabolism syndrome.
烧伤后发生的免疫反应包括一系列因自体组织受损而激活的反应，随后是受损组织和外来病原体（如入侵细菌）的清除以及组织修复。这些免疫反应被认为是生物体中预先设定好的。现代医学的发展使得以前无法治愈的烧伤患者得以挽救；然而，这种预先设定的反应已不再能跟上需求，各种问题随之出现。本文描述了烧伤特异性免疫反应的机制以及持续性炎症、免疫抑制和分解代谢综合征这一新兴概念。
