Subhadarshini Sikha, Taksande Karuna
Anaesthesiology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2024 May 18;16(5):e60575. doi: 10.7759/cureus.60575. eCollection 2024 May.
Anesthesia is critical to pediatric care, ensuring the safety and comfort of children undergoing medical procedures. With a growing interest in alternative anesthetic agents, melatonin has emerged as a promising candidate due to its sedative, analgesic, anti-inflammatory, and neuroprotective properties. This comprehensive review explores the potential applications of melatonin in pediatric anesthesia. We delve into the pharmacological characteristics of melatonin, its anesthetic properties, and its clinical applications in pediatric care, including preoperative sedation, adjunct to general anesthesia, postoperative pain management, and prevention of emergence delirium. Additionally, we discuss the safety profile of melatonin, potential adverse effects, and comparative analysis with traditional anesthetics. Finally, we highlight future research directions to provide insights into melatonin's role in pediatric anesthesia and its implications for clinical practice.
麻醉对儿科护理至关重要，可确保接受医疗程序的儿童的安全与舒适。随着对替代性麻醉剂的兴趣日益浓厚，褪黑素因其镇静、镇痛、抗炎和神经保护特性而成为一个有前景的候选药物。这篇全面综述探讨了褪黑素在儿科麻醉中的潜在应用。我们深入研究了褪黑素的药理学特性、麻醉特性及其在儿科护理中的临床应用，包括术前镇静、全身麻醉辅助、术后疼痛管理以及预防苏醒期谵妄。此外，我们讨论了褪黑素的安全性、潜在不良反应以及与传统麻醉剂的比较分析。最后，我们强调了未来的研究方向，以深入了解褪黑素在儿科麻醉中的作用及其对临床实践的影响。
