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用于治疗自身免疫性和炎性疾病的新型酪氨酸激酶2抑制剂

Novel Tyrosine Kinase 2 Inhibitors for Treating Autoimmune and Inflammatory Diseases.

作者信息

Sabnis Ram W

机构信息

Smith, Gambrell & Russell LLP, 1105 W. Peachtree Street NE, Suite 1000, Atlanta, Georgia 30309, United States.

出版信息

ACS Med Chem Lett. 2024 May 16;15(6):769-770. doi: 10.1021/acsmedchemlett.4c00196. eCollection 2024 Jun 13.

Abstract

Provided herein are novel tyrosine kinase 2 inhibitors, pharmaceutical compositions, use of such compounds in treating autoimmune and inflammatory diseases, and processes for preparing such compounds.

摘要

本文提供了新型酪氨酸激酶2抑制剂、药物组合物、此类化合物在治疗自身免疫性和炎性疾病中的用途,以及制备此类化合物的方法。

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引用本文的文献

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Novel TYK2 Inhibitors for Treating Autoimmune and Inflammatory Diseases.
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本文引用的文献

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TYK2 Inhibitors for Treating Autoimmune and Inflammatory Diseases.
ACS Med Chem Lett. 2024 Feb 6;15(3):320-321. doi: 10.1021/acsmedchemlett.4c00024. eCollection 2024 Mar 14.
2
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Int Immunopharmacol. 2024 Jan 5;126:111238. doi: 10.1016/j.intimp.2023.111238. Epub 2023 Nov 20.
3
Discovery of WD-890: A novel allosteric TYK2 inhibitor for the treatment of multiple autoimmune diseases.
Biomed Pharmacother. 2023 Nov;167:115611. doi: 10.1016/j.biopha.2023.115611. Epub 2023 Sep 29.
4
Signaling pathways in macrophages: molecular mechanisms and therapeutic targets.
MedComm (2020). 2023 Sep 11;4(5):e349. doi: 10.1002/mco2.349. eCollection 2023 Oct.
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Ubiquitination network in the type I IFN-induced antiviral signaling pathway.
Eur J Immunol. 2023 Sep;53(9):e2350384. doi: 10.1002/eji.202350384. Epub 2023 May 28.
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Deucravacitinib is an allosteric TYK2 protein kinase inhibitor FDA-approved for the treatment of psoriasis.
Pharmacol Res. 2023 Mar;189:106642. doi: 10.1016/j.phrs.2022.106642. Epub 2023 Feb 6.

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