Zhang Jiawen, Gu Duoduo, Yan Yang, Pan Ruoxin, Zhong Hui, Zhang Chengfeng, Xu Yang
Department of Dermatology, Huashan Hospital of Fudan University, Shanghai, People's Republic of China.
Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Clin Cosmet Investig Dermatol. 2024 Jun 14;17:1405-1412. doi: 10.2147/CCID.S473598. eCollection 2024.
Rosacea is a chronic inflammatory skin disease that affects a patient's appearance and quality of life. It mainly affects the midface region and presents as erythema, flushing, telangiectasia, papules, pustules, and rhinophyma. Despite its prevalence, the precise pathophysiology of rosacea remains unknown, and novel pharmacological therapies are currently under investigation. Tranexamic acid (TA) is a synthetic, lysine-like compound that competitively inhibits fibrinogen production by synthesizing fibrinolytic enzymes. In addition to its popular application in hemorrhage treatment, TA has been used to manage a number of skin conditions, including melasma, chronic urticaria, and angioedema. TA is a better option for melasma treatment. However, the role of TA in treating rosacea has not yet been systematically elucidated. In this study, we reviewed all available literature on the use of TA for rosacea treatment. The included articles examined the therapeutic effects of TA in patients with rosacea, including traditional methods such as oral and topical administration and more novel approaches such as intradermal injections, microneedling, and laser-assisted delivery. Several recent clinical studies demonstrated that TA alleviates rosacea symptoms by restoring the permeability barrier, ameliorating the immune reaction, and inhibiting angiogenesis. In this review, we summarized the function and potential application of TA in rosacea treatment, aiming to facilitate the implementation of clinical applications.
酒渣鼻是一种慢性炎症性皮肤病，会影响患者的外貌和生活质量。它主要影响面部中部区域，表现为红斑、潮红、毛细血管扩张、丘疹、脓疱和鼻赘。尽管酒渣鼻很常见，但其确切的病理生理学仍然未知，目前正在研究新的药物疗法。氨甲环酸（TA）是一种合成的、类似赖氨酸的化合物，通过合成纤溶酶竞争性抑制纤维蛋白原的产生。除了在出血治疗中的广泛应用外，TA还被用于治疗多种皮肤疾病，包括黄褐斑、慢性荨麻疹和血管性水肿。TA是治疗黄褐斑的更好选择。然而，TA在治疗酒渣鼻方面的作用尚未得到系统阐明。在本研究中，我们回顾了所有关于使用TA治疗酒渣鼻的现有文献。纳入的文章研究了TA对酒渣鼻患者的治疗效果，包括口服和外用等传统方法以及皮内注射、微针和激光辅助给药等更新颖的方法。最近的几项临床研究表明，TA通过恢复渗透屏障、改善免疫反应和抑制血管生成来缓解酒渣鼻症状。在本综述中，我们总结了TA在酒渣鼻治疗中的作用和潜在应用，旨在促进临床应用的实施。
