Department of Intensive Care Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing Key Laboratory of Emergency Medicine, Chongqing 400016, China.
Nursing Office of General Hospital of Xinjiang Military Region, Wulumuqi 830013, China.
Psychiatry Res. 2024 Sep;339:116043. doi: 10.1016/j.psychres.2024.116043. Epub 2024 Jun 15.
3,4-methylenedioxymethamphetamine (MDMA), commonly known as ecstasy, is one of the most widely used illicit substances worldwide. MDMA-assisted psychotherapy has become a novel treatment for posttraumatic stress disorder (PTSD), and many randomized controlled trials (RCTs) have been performed over the past decade. Therefore, this study aimed to systematically review and demonstrate the efficacy and safety of MDMA-assisted psychotherapy for the treatment of PTSD. We conducted a systematic search of PubMed, Embase, and Web of Science databases up to October 27, 2023, selected RCTs assessing the efficacy and safety of MDMA-assisted psychotherapy for the treatment of PTSD, and evaluated their quality using the Cochrane risk of bias tool. Seven RCTs were selected from the retrieved references. The results revealed that MDMA-assisted psychotherapy effectively reduced the change from baseline score in the Clinician-Administered PTSD Scale in patients with PTSD compared with either placebo or active controls. However, MDMA causes a series of adverse events, including muscle tightness, nausea, and decreased appetite. To a certain extent, MDMA-assisted psychotherapy may improve symptoms in patients with PTSD. However, side effects and abuse issues still seriously hinder clinical application of MDMA.
3,4-亚甲二氧基甲基苯丙胺（MDMA），俗称摇头丸，是世界上使用最广泛的非法物质之一。MDMA 辅助心理治疗已成为治疗创伤后应激障碍（PTSD）的一种新方法，在过去十年中已经进行了许多随机对照试验（RCT）。因此，本研究旨在系统地回顾和展示 MDMA 辅助心理治疗治疗 PTSD 的疗效和安全性。我们对 PubMed、Embase 和 Web of Science 数据库进行了系统检索，截至 2023 年 10 月 27 日，选择了评估 MDMA 辅助心理治疗治疗 PTSD 的疗效和安全性的 RCT，并使用 Cochrane 偏倚风险工具评估其质量。从检索到的参考文献中选择了 7 项 RCT。结果表明，与安慰剂或活性对照相比，MDMA 辅助心理治疗可有效降低 PTSD 患者从基线评分开始的 Clinician-Administered PTSD Scale 变化。然而，MDMA 会引起一系列不良反应，包括肌肉紧张、恶心和食欲下降。在一定程度上，MDMA 辅助心理治疗可能会改善 PTSD 患者的症状。然而，副作用和滥用问题仍然严重阻碍了 MDMA 的临床应用。
