手足锻炼对结直肠癌化疗引起的周围神经病变相关疼痛、跌倒和生活质量的影响：一项随机对照试验。

The effect of hand-foot exercises on chemotherapy-induced peripheral neuropathy-related pain, falls, and quality of life in colorectal cancer: A randomized controlled trial.

机构信息

Ankara University Nursing Faculty, Department of Internal Medicine Nursing, Ankara, Turkey.

出版信息

Eur J Oncol Nurs. 2024 Aug;71:102641. doi: 10.1016/j.ejon.2024.102641. Epub 2024 Jun 15.

DOI:10.1016/j.ejon.2024.102641

PMID:38897103

Abstract

PURPOSE

The aim of this study is to determine the effect of hand-foot exercises on chemotherapy-induced peripheral neuropathy-related pain severity, falls, and quality of life in patients with colorectal cancer.

METHODS

The study was conducted in the outpatient chemotherapy unit of a public hospital between 25 April-31 December 2022. The enrolled 39 patients were randomly assigned to the intervention (n:19) and control (n:20) groups. The hand-foot exercises program was applied to the intervention group in three sessions a day and three days a week fashion for 8 weeks at home. No intervention was applied to the control group other than routine treatment and care. Data were collected through face-to-face interviews in the first interview and the 2nd, 4th, 6th, 8th weeks. The exercise program adherence of the intervention group was followed up through telephone/face-to-face interviews in weeks 1-8. Data were collected using the Numerical Pain Rating Scale, Fall Follow-Up Form, the CIPNAT scale, EORTC QLQ-C30 and EORTC QLQ-CR29 scales. Mann-Whitney U Test, Chi-square test, Wilcoxon signed test, and Friedman test were used to analyze the data.

RESULTS

The study found that as of week 4th, the intervention group experienced less pain severity than the control group (p < 0.001); at week 8th, the peripheral neuropathy symptoms of the intervention group decreased compared to the control group (p < 0.05); at weeks 2nd,4th,6th,8th, there was no statistically significant difference in falls (p > 0.05); at week 8th, while there was no significant difference between the groups regarding colorectal cancer quality of life (p > 0.05), the overall cancer quality of life improved in the intervention group (p < 0.05).

CONCLUSIONS

The hand-foot exercises program is effective in chemotherapy-induced peripheral neuropathy-related symptoms, pain severity, and overall cancer quality of life.

TRIAL REGISTRATION

www.

CLINICALTRIALS

gov, NCT05873829.

摘要

目的

本研究旨在确定手足锻炼对结直肠癌患者化疗引起的周围神经病变相关疼痛严重程度、跌倒和生活质量的影响。

方法

该研究于 2022 年 4 月 25 日至 12 月 31 日在一家公立医院的门诊化疗病房进行。纳入的 39 名患者被随机分配到干预组（n=19）和对照组（n=20）。干预组在家中每天进行 3 次、每周进行 3 次手足锻炼计划，持续 8 周。对照组除常规治疗和护理外，不进行任何干预。在第一次访谈和第 2、4、6、8 周进行面对面访谈收集数据。在第 1 周到第 8 周通过电话/面对面访谈对干预组的锻炼计划依从性进行随访。使用数字疼痛评分量表、跌倒随访表、CIPNAT 量表、EORTC QLQ-C30 和 EORTC QLQ-CR29 量表收集数据。采用 Mann-Whitney U 检验、卡方检验、Wilcoxon 符号秩检验和 Friedman 检验进行数据分析。

结果

研究发现，第 4 周时，干预组的疼痛严重程度低于对照组（p<0.001）；第 8 周时，干预组的周围神经病变症状较对照组减轻（p<0.05）；第 2、4、6、8 周时，跌倒无统计学差异（p>0.05）；第 8 周时，两组结直肠癌生活质量无显著差异（p>0.05），但干预组总体癌症生活质量有所改善（p<0.05）。