Morioka Harumi, Yanagihashi Masaru, Toda Mikito, Ikeda Takanori, Mizuno Masafumi, Hori Masaaki, Kamiya Kouhei, Kano Osamu
Department of Neurology, Toho University Faculty of Medicine.
Department of Cardiology, Toho University Faculty of Medicine.
J Nippon Med Sch. 2025 May 21;92(2):220-224. doi: 10.1272/jnms.JNMS.2025_92-202. Epub 2024 Jun 18.
Prosopagnosia is a cognitive disorder in which facial recognition is severely impaired despite normal vision and intelligence. Prosopagnosia was first reported in the 1800s, but its cause remains unclear. Although other neurological symptoms are often present, some patients have pure prosopagnosia. The bilateral occipital lobes are believed to be associated with symptoms. Recent brain imaging techniques have identified the right fusiform gyrus (rFG), located at the junction of the right occipital temporal lobe, as the affected region. In this report, we present a case of associative prosopagnosia with no concomitant symptoms in a 76-year-old man. Brain magnetic resonance imaging detected a subcortical hemorrhage in the right temporal lobe. Using tractography based on diffusion tensor imaging, we visualized atrophy of the right inferior longitudinal fasciculus (ILF). This is the first time tractography has been used to show a clear association between associative prosopagnosia and ILF damage projecting from the rFG.
面孔失认症是一种认知障碍，患者尽管视力和智力正常，但面部识别能力严重受损。面孔失认症最早于19世纪被报道，但其病因仍不清楚。虽然通常还会出现其他神经症状，但有些患者患有单纯性面孔失认症。双侧枕叶被认为与这些症状有关。最近的脑成像技术已确定位于右枕颞叶交界处的右侧梭状回（rFG）为受影响区域。在本报告中，我们介绍了一名76岁男性患有无伴随症状的联想性面孔失认症的病例。脑磁共振成像检测到右侧颞叶有皮质下出血。利用基于扩散张量成像的纤维束成像技术，我们观察到右侧下纵束（ILF）萎缩。这是首次使用纤维束成像技术显示联想性面孔失认症与从rFG投射出的ILF损伤之间存在明确关联。
