Adekanmbi Olukemi, Alao Adegboyega, Ibisola Babalola, Odekunle Idowu
Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Department of Family Medicine, University College Hospital, Ibadan, Ibadan, Nigeria.
Niger Med J. 2023 May 11;64(2):243-250. eCollection 2023 Mar-Apr.
COVID-19, which is caused by the SARS-CoV-2 virus, is associated with abnormalities of biochemical parameters. There are indications that some of these biochemical parameters can differ according to the severity of the disease and the outcome of the infection. This study describes and compares laboratory findings among COVID-19 patients hospitalized at a facility in Southwestern Nigeria according to disease severity and mortality.
Records of 223 patients with COVID-19 disease admitted between March 2020 and May 2021 were retrospectively collected. Socio-demographic characteristics, laboratory parameters, and patient outcomes were obtained. Patients were classified according to COVID-19 severity. Laboratory parameters were compared between patients with severe and non-severe disease and between survivors and non-survivors.
Of the 215 patients with some laboratory data included in the analysis, there were 133 (62%) males, and 56.7% were aged above 60 years. A total of 71.6% had severe COVID-19 and 48.4% died during hospitalization. The severe disease occurred significantly more frequently among non-survivors (0.01). Higher leukocyte and neutrophil counts, urea levels, D-Dimer, and fasting blood glucose levels occurred significantly more frequently in both severe disease and mortality categories. Additionally, elevated GGT and CRP were significantly more common in those with severe than non-severe disease while lower hemoglobin, hematocrit, albumin, and higher creatinine levels were significantly more common in non-survivors.
Our study found that certain readily obtainable biochemical parameters occur more frequently with severe disease and/or mortality amongst patients hospitalized with COVID-19 in sub-Saharan Africa and might be useful for prognostication and allocation of resources.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒引起的2019冠状病毒病（COVID-19）与生化参数异常有关。有迹象表明，其中一些生化参数可能因疾病严重程度和感染结果而异。本研究描述并比较了在尼日利亚西南部一家医疗机构住院的COVID-19患者根据疾病严重程度和死亡率的实验室检查结果。
回顾性收集了2020年3月至2021年5月期间收治的223例COVID-19患者的记录。获取了社会人口统计学特征、实验室参数和患者结局。根据COVID-19严重程度对患者进行分类。比较了重症和非重症患者以及幸存者和非幸存者之间的实验室参数。
在纳入分析的215例有一些实验室数据的患者中，男性133例（62%），56.7%的患者年龄在60岁以上。共有71.6%的患者患有重症COVID-19，48.4%的患者在住院期间死亡。非幸存者中重症疾病的发生率明显更高（0.01）。白细胞和中性粒细胞计数、尿素水平、D-二聚体和空腹血糖水平在重症疾病和死亡类别中明显更频繁地出现。此外，γ-谷氨酰转移酶（GGT）和C反应蛋白（CRP）升高在重症患者中比非重症患者更常见，而血红蛋白、血细胞比容、白蛋白降低和肌酐水平升高在非幸存者中更常见。
我们的研究发现，在撒哈拉以南非洲地区住院的COVID-19患者中，某些易于获得的生化参数在重症疾病和/或死亡中更频繁出现，可能有助于预后评估和资源分配。
