Mainland Hospital, Yaba, Lagos, Nigeria.
Lagos State Ministry of Health, Lagos, Nigeria.
Pan Afr Med J. 2020 May 6;35(Suppl 2):24. doi: 10.11604/pamj.supp.2020.35.2.23262. eCollection 2020.
Success in curtailing the pandemic coronavirus disease (COVID-19) depends largely on a sound understanding of the epidemiologic and clinical profile of cases in a population as well as the case management approach. This study documents the presenting characteristics, treatment modalities and outcomes of the first 32 COVID-19 patients in Nigeria.
This retrospective study used medical records of the first 32 patients admitted and discharged from the Mainland Hospital, Lagos State, southwest Nigeria between February 27 and April 6, 2020. The outcomes of interest were death, promptness of admission process and duration of hospitalization.
The mean age of the patients was 38.1 years (SD: 15.5) and 66% were male. Three-quarters (75%) of the patients presented in moderately severe condition while 16% were asymptomatic. The most common presenting symptoms were fever (59%) and dry cough (44%). The mean time between a positive test result and admission was 1.63 days (SD: 1.31). Almost all (97%) the patients were treated with lopinavir-ritonavir with no recorded death. The median duration of hospital stay was 12 days (IQR: 9-13.5).
In this preliminary analysis of the first COVID-19 cases in Nigeria, clinical presentation was mild to moderate with no mortality. Processes to improve promptness of admission and reduce hospital stay are required to enhance the response to COVID-19 in Nigeria.
成功控制大流行冠状病毒病（COVID-19）在很大程度上取决于对人群中病例的流行病学和临床特征以及病例管理方法的充分了解。本研究记录了尼日利亚首例 32 例 COVID-19 患者的临床表现、治疗方式和结局。
本回顾性研究使用了 2020 年 2 月 27 日至 4 月 6 日期间拉各斯州大陆医院收治和出院的前 32 名患者的病历。感兴趣的结局是死亡、入院过程的及时性和住院时间。
患者的平均年龄为 38.1 岁（SD：15.5），66%为男性。四分之三（75%）的患者病情中度严重，16%的患者无症状。最常见的症状是发热（59%）和干咳（44%）。阳性检测结果与入院之间的平均时间为 1.63 天（SD：1.31）。几乎所有（97%）患者均接受洛匹那韦-利托那韦治疗，无死亡记录。住院中位数为 12 天（IQR：9-13.5）。
在尼日利亚首例 COVID-19 病例的初步分析中，临床表现为轻度至中度，无死亡病例。需要改进入院及时性和缩短住院时间的流程，以加强尼日利亚对 COVID-19 的应对。
