Öztürk Atkaya Neşe, Özdel İsmail Osman, Türel Samet, Tepeli Emre
Department of Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, TUR.
Department of Medical Genetics, Faculty of Medicine, Pamukkale University, Denizli, TUR.
Cureus. 2024 May 20;16(5):e60654. doi: 10.7759/cureus.60654. eCollection 2024 May.
The aim of this study is to investigate sexual dysfunctions (SDs) and related factors in patients with schizophrenia and bipolar disorder receiving pharmacotherapy.
This study included 111 patients. The Scale for the Assessment of Positive Symptoms (SAPS), the Scale for the Assessment of Negative Symptoms (SANS), and the Calgary Depression Scale for Schizophrenia (CDSS) were applied to the schizophrenia, and the Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HAM-D) to the bipolar patient group. The sociodemographic data form and the Arizona Sexual Experiences Scale (ASEX) were applied to both of the patient groups. Blood was drawn from all patients to evaluate the indicated gene polymorphisms and evaluate prolactin levels.
SD was detected in 45.9% (N = 34) of the schizophrenia group, and 59.5% (N = 22) in the bipolar disorder group. SD was significantly higher in elderly patients and patients with a high smoking amount and low education levels. The eNOS -786T>C T allele frequency was found to be significantly higher in patients with SD. The logistic regression analysis determined that eNOS -786T>C CT and TT genotypes increased the risk of SD.
In this study, the high rates of SD in patients with schizophrenia and bipolar disorder, and the presence of modifiable factors that influence the presence of SD, suggest that SD should be given more attention in these patient groups. On the other hand, the high rate of SD in patients with the eNOS -786T>C T allele indicates the importance of carrying out new studies investigating the factors affecting the enzyme activity in this genotype. There is a need for more studies on eNOS genotypes and enzyme activites in this area.
本研究旨在调查接受药物治疗的精神分裂症和双相情感障碍患者的性功能障碍（SDs）及相关因素。
本研究纳入111例患者。对精神分裂症患者应用阳性症状评定量表（SAPS）、阴性症状评定量表（SANS）和精神分裂症卡尔加里抑郁量表（CDSS），对双相情感障碍患者组应用青年躁狂评定量表（YMRS）和汉密尔顿抑郁评定量表（HAM-D）。对两组患者均应用社会人口统计学数据表格和亚利桑那性体验量表（ASEX）。采集所有患者的血液以评估指定的基因多态性并检测催乳素水平。
精神分裂症组中45.9%（N = 34）检测到性功能障碍，双相情感障碍组中为59.5%（N = 22）。老年患者、吸烟量高和教育水平低的患者性功能障碍发生率显著更高。发现性功能障碍患者的内皮型一氧化氮合酶（eNOS）-786T>C T等位基因频率显著更高。逻辑回归分析确定eNOS -786T>C CT和TT基因型增加了性功能障碍的风险。
在本研究中，精神分裂症和双相情感障碍患者性功能障碍发生率高，且存在影响性功能障碍发生的可改变因素，这表明在这些患者群体中应更关注性功能障碍。另一方面，携带eNOS -786T>C T等位基因的患者性功能障碍发生率高，这表明开展新研究调查影响该基因型酶活性的因素具有重要意义。该领域需要更多关于eNOS基因型和酶活性的研究。
