Cutaneous Reactive Lymphoid Proliferation Arising in the Setting of Concomitant Antidepressant and Antihypertensive Therapy.

Cutaneous reactive lymphoid proliferation (CRLP) is a condition that resembles cutaneous lymphoma, and differentiating the two is necessary for proper diagnosis and treatment. It can be idiopathic or caused by viruses, drugs, or skin trauma, resulting in reactive lymphoid hyperplasia. Several clinical and histopathological features are helpful for differentiating CRLP from lymphoma, and they must be considered as a whole to reach the correct diagnosis. The number, location, and progression of CRLP lesions are important clinical clues, while the type, size, arrangement, surface markers, and clonality of the cellular infiltrate are key histopathological clues. We present a case in which CRLP arose in the setting of concomitant antidepressant and antihypertensive use, which are both potential causes of CRLP. In this case, excision served as both diagnosis and treatment. The benign presentation and lack of clonality led to the diagnosis of CRLP. While the cause is unknown, drug exposure was a possible inciting factor, and the patient will be monitored for recurrence.