Hu Qiao-Ling, Zeng Chao
Department of Pathology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen 518000, Guangdong Province, China.
World J Clin Cases. 2024 Jun 6;12(16):2887-2893. doi: 10.12998/wjcc.v12.i16.2887.
We present a case of an rearranged sarcoma in the left forearm and analyze its clinicopathological and molecular features.
The patient is a 23-year-old woman. Microscopically, the tumor cells were medium-sized round cells arranged in small nests. The cytoplasm was clear, nuclei were relatively uniform, chromatin was dense, nucleoli were visible, and mitotic figures were rare. Immunohistochemically, the tumor cells were positive for Vimentin, INI-1, CD99, NKX2.2, CyclinD1, friend leukaemia virus integration 1, and NKX3.1. Next-generation sequencing revealed the presence of the fusion gene. rearranged sarcomas are rare and can easily be misdiagnosed.
Clinical imaging, immunohistochemistry, and molecular pathology should be considered to confirm the diagnosis.
我们报告一例左前臂重排肉瘤病例，并分析其临床病理和分子特征。
患者为一名23岁女性。显微镜下，肿瘤细胞为中等大小的圆形细胞，呈小巢状排列。细胞质清晰，细胞核相对均匀，染色质致密，可见核仁，有丝分裂象罕见。免疫组化显示，肿瘤细胞波形蛋白、INI-1、CD99、NKX2.2、细胞周期蛋白D1、Friend白血病病毒整合1和NKX3.1呈阳性。二代测序显示存在融合基因。重排肉瘤罕见，易被误诊。
应考虑通过临床影像学、免疫组化和分子病理学来确诊。
