Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
China-Cameroon Joint Laboratory on Bioactive Natural Products from Endophytes, Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266071, People's Republic of China.
Bioorg Chem. 2024 Sep;150:107572. doi: 10.1016/j.bioorg.2024.107572. Epub 2024 Jun 17.
The fast spread of antibiotic resistance results in the requirement for a constant introduction of new candidates. Pentangular polyphenols, a growing family of actinomycetes-derived aromatic type II polyketides, have attracted considerable attention due to their intriguing polycyclic systems and potent antimicrobial activity. Among them, benastatins, anthrabenzoxocinones (ABXs), and fredericamycins, display unique variations in their polycyclic frameworks, yet concurrently share structural commonalities within their substitutions. The present review summarizes advances in the isolation, spectroscopic characteristics, biosynthesis, and biological activities of pentangular polyphenols benastatins (1-16), ABXs (17-39), and fredericamycins (40-42) from actinomycetes. The information presented here thus prompts researchers to further explore and discover additional congeners within these three small classes of pentangular polyphenols.
抗生素耐药性的快速传播导致不断需要引入新的候选药物。五角多酚是一类不断发展的放线菌来源的芳香型 II 型聚酮化合物，由于其引人入胜的多环系统和强大的抗菌活性而引起了相当大的关注。其中，benastatins、anthrabenzoxocinones (ABXs) 和 fredericamycins 在其多环骨架中表现出独特的变化，但在取代基方面具有结构上的共同性。本综述总结了从放线菌中分离出的五角多酚 benastatins（1-16）、ABXs（17-39）和 fredericamycins（40-42）的分离、光谱特征、生物合成和生物活性方面的进展。因此，这里提供的信息促使研究人员进一步探索和发现这三个五角多酚小类中的其他同系物。
