Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran; USERN Office, Qazvin University of Medical science, Qazvin, Iran.
USERN Office, Qazvin University of Medical science, Qazvin, Iran; Cellular and Molecular Research Center, Research Institute for prevention of Non- Communicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran.
Cell Immunol. 2024 Jul-Aug;401-402:104844. doi: 10.1016/j.cellimm.2024.104844. Epub 2024 Jun 18.
The gastrointestinal (GI) tract and the brain form bidirectional nervous, immune, and endocrine communications known as the gut-brain axis. Several factors can affect this axis; among them, various studies have focused on the microbiota and imply that alterations in microbiota combinations can influence both the brain and GI. Also, many studies have shown that the immune system has a vital role in varying gut microbiota combinations. In the current paper, we will review the multidirectional effects of gut microbiota, immune system, and nervous system on each other. Specifically, this review mainly focuses on the impact of Peyer's patches as a critical component of the gut immune system on the gut-brain axis through affecting the gut's microbial composition. In this way, some factors were discussed as proposed elements of missing gaps in this field.
胃肠道（GI）和大脑形成双向的神经、免疫和内分泌通讯，称为肠脑轴。有几个因素可以影响这个轴；其中，许多研究集中在微生物群上，并表明微生物群组合的改变可以影响大脑和胃肠道。此外，许多研究表明免疫系统在改变肠道微生物群组合方面起着至关重要的作用。在本文中，我们将综述肠道微生物群、免疫系统和神经系统之间的相互多向影响。具体来说，本综述主要关注作为肠道免疫系统关键组成部分的派尔集合淋巴结如何通过影响肠道微生物组成来影响肠脑轴。通过这种方式，讨论了一些因素，这些因素被认为是该领域缺失环节的要素。
