C-reactive protein. Properties and biological action with particular reference to systemic lupus erythematosus.

A dramatic increase in serum C-reactive protein levels occurs in response to specific bacterial infection or tissue damage. This protein forms part of the acute-phase response, and it appears to function as an independent but relatively nonspecific part of the immune response. It has many properties in common with specific IgG. Absence of an adequate C-reactive protein response may play a role in the pathogenesis of systemic lupus erythematosus.