Yang Menghan, Zhang Yingying, Zhang Tianyu, Zhou Huanyu, Ren Jiechuan, Zhou Dong, Yang Tianhua
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Front Neurol. 2024 Jun 6;15:1373125. doi: 10.3389/fneur.2024.1373125. eCollection 2024.
To investigate whether changes occur in the dynamic functional connectivity (dFC) of motor cerebellum with cerebral cortex in juvenile myoclonic epilepsy (JME).
We adopted resting-state electroencephalography-functional magnetic resonance imaging (EEG-fMRI) and a sliding-window approach to explore the dFC of motor cerebellum with cortex in 36 JME patients compared with 30 and age-matched health controls (HCs). The motor cerebellum was divided into five lobules (I-V, VI, VIIb, VIIIa, and VIIIb). Additionally, correlation analyses were conducted between the variability of dFC and clinical variables in the Juvenile Myoclonic Epilepsy (JME) group, such as disease duration, age at disease onset, and frequency score of myoclonic seizures.
Compared to HCs, the JME group presented increased dFC between the motor cerebellum with SMN and DMN. Specifically, connectivity between lobule VIIb and left precentral gyrus and right inferior parietal lobule (IPL); between lobule VIIIa and right inferior frontal gyrus (IFG) and left IPL; and between lobule VIIIb and left middle frontal gyrus (MFG), bilateral superior parietal gyrus (SPG), and left precuneus. In addition, within the JME group, the strength of dFC between lobule VIIIb and left precuneus was negatively ( = -0.424, = 0.025, Bonferroni correction) related with the frequency score of myoclonic seizures.
In patients with JME, there is a functional dysregulation between the motor cerebellum with DMN and SMN, and the variability of dynamic functional connectivity may be closely associated with the occurrence of motor symptoms in JME.
探讨青少年肌阵挛癫痫（JME）患者运动小脑与大脑皮层之间的动态功能连接（dFC）是否发生变化。
我们采用静息态脑电图-功能磁共振成像（EEG-fMRI）和滑动窗口方法，对36例JME患者与30例年龄匹配的健康对照（HCs）进行运动小脑与皮层的dFC研究。运动小脑被分为五个小叶（I-V、VI、VIIb、VIIIa和VIIIb）。此外，在青少年肌阵挛癫痫（JME）组中，对dFC的变异性与临床变量之间进行相关性分析，如病程、发病年龄和肌阵挛发作频率评分。
与HCs相比，JME组运动小脑与默认模式网络（DMN）和感觉运动网络（SMN）之间的dFC增加。具体而言，小叶VIIb与左侧中央前回和右侧顶下小叶（IPL）之间；小叶VIIIa与右侧额下回（IFG）和左侧IPL之间；小叶VIIIb与左侧额中回（MFG）、双侧顶上小叶（SPG）和左侧楔前叶之间的连接。此外，在JME组内，小叶VIIIb与左侧楔前叶之间的dFC强度与肌阵挛发作频率评分呈负相关（r = -0.424，p = 0.025，Bonferroni校正）。
在JME患者中，运动小脑与DMN和SMN之间存在功能失调，动态功能连接的变异性可能与JME运动症状的发生密切相关。
