Saurat J H
Acta Derm Venereol Suppl (Stockh). 1985;114:125-8.
Eczema is one of the cutaneous manifestations of primary immune deficiencies. It may therefore serve as a model for the understanding of atopic dermatitis (AD) provided the eczema in the immune deficiency under consideration is a constant feature and is similar to AD. In the Wiskott-Aldrich syndrome the eczematous eruption is (i) a constant feature of the syndrome, (ii) indistinguishable from AD when diagnostic criteria for AD are used, and (iii) clears dramatically after a successful bone marrow graft, which suggests that immune dysfunction is directly involved in the pathogenesis of the eczema.
湿疹是原发性免疫缺陷的皮肤表现之一。因此，如果所考虑的免疫缺陷中的湿疹是一个持续特征且与特应性皮炎（AD）相似，那么它可以作为理解特应性皮炎的模型。在维斯科特-奥尔德里奇综合征中，湿疹性皮疹：（i）是该综合征的一个持续特征；（ii）使用AD的诊断标准时与AD难以区分；（iii）在成功进行骨髓移植后显著消退，这表明免疫功能障碍直接参与了湿疹的发病机制。
