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老年人听力损失评估与白细胞介素 2(IL-2)血浆水平的相关性。

Plasma Levels of Interleukin 2 (IL-2) Associated with Hearing Loss Evaluation in the Elderly.

机构信息

Student of theMaster's and Doctor's Degree in Rehabilitation Sciences, UEL-UNOPAR. https://orcid.org/0000-0003-4489-2568.

Interdisciplinary Laboratory for Intervention in Health Promotion LIIPS/UNICESUMAR-Maringá, Paraná, Brazil https://orcid.org/0000-0002-9026-0468.

出版信息

Noise Health. 2024;26(121):165-173. doi: 10.4103/nah.nah_3_23. Epub 2024 Jun 21.

Abstract

CONTEXT

Presbycusis can be mediated by the effects of inflammatory processes on the auditory system, and these aging biological mechanisms remain poorly studied.

AIMS

The aim of this study was to determine whether plasma biomarkers are associated with hearing disorders caused by aging in the elderly.

SETTINGS AND DESIGN

Cross-sectional study with 106 participants in the Active Aging Project, 93 (88%) females and 13 (12%) males, with an average age of 70 years.

METHODS AND MATERIAL

Audiological evaluation was performed with pure tone audiometry and collection of peripheral blood for the measurement of plasma levels of interleukins 2, 4, 6, and 10, tumor necrosis factor-α, and interferon-γ by means of flow cytometry.

STATISTICAL ANALYSIS USED

The SPSS (v.0, SPSS Inc., Chicago, USA) was used for the analysis of the data obtained. For all data analyzed, the significance level adopted was P < 0.05 and 95% confidence interval.

RESULTS

There were statistically significant correlations between male and IL-2 (P = 0.031; rs = 0.210), mean II of the right ear (P = 0.004; rs = 0.279), longer in years (P = 0.002; rs = 0.307) and in hours (P = 0.004; rs = 0.281) of noise exposure also in males.

CONCLUSIONS

In the present study, there was an association between the male gender and higher plasma levels of IL-2, an increase in the average hearing in the right ear, and greater time in years and hours of exposure to noise. There was a predominance of mild sensorineural hearing loss and worsening of hearing related to age, characteristics of presbycusis.

摘要

背景

耳背可以通过炎症过程对听觉系统的影响来介导,这些衰老的生物学机制仍未得到充分研究。

目的

本研究旨在确定血浆生物标志物是否与老年人因衰老引起的听力障碍有关。

设置和设计

横断面研究,共有 106 名参与者参加了积极老龄化项目,其中 93 名(88%)为女性,13 名(12%)为男性,平均年龄为 70 岁。

方法和材料

使用纯音听阈测试进行听力学评估,并采集外周血样,通过流式细胞术测量白细胞介素 2、4、6 和 10、肿瘤坏死因子-α和干扰素-γ的血浆水平。

使用的统计分析

使用 SPSS(v.0,SPSS Inc.,芝加哥,美国)对获得的数据进行分析。对于所有分析的数据,采用 P < 0.05 和 95%置信区间的显著性水平。

结果

男性与白细胞介素 2(P = 0.031;rs = 0.210)、右耳平均 II(P = 0.004;rs = 0.279)、更长的年龄(P = 0.002;rs = 0.307)和噪声暴露时间(P = 0.004;rs = 0.281)之间存在统计学显著相关性。

结论

在本研究中,男性性别与较高的白细胞介素 2血浆水平、右耳平均听力增加以及年龄和噪声暴露时间增加有关。存在以轻度感音神经性听力损失为主,与年龄相关的听力下降的特点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aedd/11530100/a84bbe6ff429/NH-26-165-g001.jpg

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