Chafetz N, Hattner R S, Ruarke W C, Helms C A, Genant H K, Murray W R
AJR Am J Roentgenol. 1985 Jun;144(6):1255-8. doi: 10.2214/ajr.144.6.1255.
One hundred eleven patients with symptomatic prosthetic joints (86 hips, 23 knees, and two shoulders) were evaluated for prosthetic loosening and infection by combined technetium-99m-MDP/gallium-67 digital subtraction imaging. Clinical correlation was based on the assessment of loosening and bacterial cultures obtained at the time of surgery in 54 patients, joint aspiration cultures obtained in 37 patients, and long-term clinical follow-up for greater than 1.5 years in an additional 15 patients. Results revealed an 80%-90% predictive value of a positive test for loosening, and a 95% predictive value of a negative test for infection. However, because of the low sensitivities and specificities observed, this approach to the evaluation of symptomatic prosthetic joints does not seem cost effective.
111例有症状的人工关节患者（86例髋关节、23例膝关节和2例肩关节）通过联合使用锝-99m-亚甲基二膦酸盐/镓-67数字减影成像评估人工关节松动和感染情况。临床相关性基于对54例患者手术时获得的松动评估和细菌培养、37例患者获得的关节穿刺培养，以及另外15例患者超过1.5年的长期临床随访。结果显示，检测结果呈阳性对松动的预测价值为80% - 90%，检测结果呈阴性对感染的预测价值为95%。然而，由于观察到的敏感性和特异性较低，这种评估有症状人工关节的方法似乎不具有成本效益。
