Rho GTPase-activating protein 4 在肾透明细胞癌中上调，与不良预后和免疫浸润相关。
Rho GTPase-activating protein 4 is upregulated in Kidney Renal Clear Cell Carcinoma and associated with poor prognosis and immune infiltration.
机构信息
Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China.
Department of Stomatology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China.
出版信息
Cancer Biomark. 2024;40(2):205-223. doi: 10.3233/CBM-230388.
BACKGROUND
Kidney Renal Clear Cell Carcinoma (KIRC) is a malignant tumor that seriously threatens human health. Rho GTPase-activating protein 4 (ARHGAP4) plays an important role in the occurrence and development of tumors.
OBJECTIVE
The purpose of this study was to explore the role of ARHGAP4 in the progression of KIRC and its diagnostic and prognostic value.
METHODS
Multiple analytical methods and in vitro cell assays were used to explore the expression of ARHGAP4 and its value in the progression, diagnosis and prognosis of KIRC. The biological function of ARHGAP4 was studied by GO analysis and KEGG pathway analysis, and then the relationship between ARHGAP4 and immune infiltration was analyzed.
RESULTS
The expression of ARHGAP4 was significantly up-regulated in KIRC. We found that the high expression of ARHGAP4 was related to the progression of KIRC and suggested a poor prognosis. Compared with normal tissues, ARHGAP4 had a better diagnostic value in KIRC. The biological function of ARHGAP4 was related to immunity, and its expression was also closely related to tumor immune infiltration and immune checkpoints.
CONCLUSIONS
Our study demonstrated that ARHGAP4 may be a biomarker, which is related to the progression, diagnosis and prognosis of KIRC. Its biological functions are related to tumor immune infiltration.
背景
肾透明细胞癌（KIRC）是一种严重威胁人类健康的恶性肿瘤。Rho GTP 酶激活蛋白 4（ARHGAP4）在肿瘤的发生和发展中起着重要作用。
目的
本研究旨在探讨 ARHGAP4 在 KIRC 进展中的作用及其诊断和预后价值。
方法
采用多种分析方法和体外细胞实验，探讨 ARHGAP4 的表达及其在 KIRC 进展、诊断和预后中的价值。通过 GO 分析和 KEGG 通路分析研究 ARHGAP4 的生物学功能，然后分析 ARHGAP4 与免疫浸润的关系。
结果
ARHGAP4 在 KIRC 中表达明显上调。我们发现，ARHGAP4 的高表达与 KIRC 的进展有关，并提示预后不良。与正常组织相比，ARHGAP4 在 KIRC 中具有更好的诊断价值。ARHGAP4 的生物学功能与免疫有关，其表达也与肿瘤免疫浸润和免疫检查点密切相关。
结论
我们的研究表明，ARHGAP4 可能是一种与 KIRC 进展、诊断和预后相关的生物标志物。其生物学功能与肿瘤免疫浸润有关。
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