Abate Biruk Beletew, Tegegne Kindie Mekuria, Zemariam Alemu Birara, Wondmagegn Alamaw Addis, Kassa Mulat Awoke, Kitaw Tegene Atamenta, Abebe Gebremeskel Kibret, Azmeraw Bizuayehu Molla
Assistant Professor in Pediatrics and Child Health Nursing, College of Health Science, Woldia University, Weldiya, Ethiopia.
MSc in Psychiatry, College of Health Science, Woldia University, Weldiya, Ethiopia.
PLOS Glob Public Health. 2024 Jun 21;4(6):e0003003. doi: 10.1371/journal.pgph.0003003. eCollection 2024.
Cerebral palsy (CP) is the most common motor disability in childhood which causes a child's behavioral, feeding, and sleep difficulties. It remains a poorly studied health problem in Africa. The main aim of this study was assessing the pooled prevalence of Cerebral Palsy (CP) and its clinical characteristics in Africa context. Systematic review and meta-analysis were conducted using Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines to search articles from electronic databases (Cochrane library, Ovid platform) (Medline, Embase, and Emcare), Google Scholar, CINAHL, PubMed, Maternity and Infant Care Database (MIDIRS). The last search date was on 12/05/ 2023 G. C. A weighted inverse variance random-effects model was used to estimate the pooled estimates of cerebral palsy and its types. The subgroup analysis, publication bias and sensitivity analysis were done. Studies on prevalence and clinical characteristics of cerebral palsy were included. The primary and secondary outcomes were prevalence and clinical characteristics of cerebral palsy respectively. A total of 15 articles with (n = 498406 patients) were included for the final analysis. The pooled prevalence of cerebral palsy in Africa was found to be 3·34 (2·70, 3·98). The most common type is spastic cerebral palsy accounting 69·30% (66·76, 71·83) of all cases. The second one is quadriplegic cerebral palsy which was found to be 41·49% (33·16, 49·81). Ataxic cerebral palsy accounted 5·36% (3·22, 7·50). On the other hand, dyskinetic cerebral palsy was found to be 10.88% (6·26, 15·49). About 32·10% (19·25, 44.95) of cases were bilateral while 25·17% (16·84, 33·50) were unilateral. The incidence of cerebral palsy in Africa surpasses the reported rates in developed nations. Spastic and quadriplegic subtypes emerge as the most frequently observed. It is recommended to channel initiatives toward the strategic focus on preventive measures, early detection strategies, and comprehensive management protocols.
脑瘫（CP）是儿童期最常见的运动障碍，会导致儿童出现行为、进食和睡眠方面的困难。在非洲，这仍是一个研究较少的健康问题。本研究的主要目的是评估非洲地区脑瘫（CP）的合并患病率及其临床特征。采用系统评价和Meta分析的首选报告项目（PRISMA）指南进行系统评价和Meta分析，以检索电子数据库（Cochrane图书馆、Ovid平台）（Medline、Embase和Emcare）、谷歌学术、CINAHL、PubMed、母婴护理数据库（MIDIRS）中的文章。最后一次检索日期为公元2023年5月12日。采用加权逆方差随机效应模型来估计脑瘫及其类型的合并估计值。进行了亚组分析、发表偏倚分析和敏感性分析。纳入了关于脑瘫患病率和临床特征的研究。主要结局和次要结局分别是脑瘫的患病率和临床特征。最终分析共纳入15篇文章（n = 498406例患者）。非洲地区脑瘫的合并患病率为3.34（2.70，3.98）。最常见的类型是痉挛型脑瘫，占所有病例的69.30%（66.76，71.83）。其次是四肢瘫型脑瘫，占41.49%（33.16，49.81）。共济失调型脑瘫占5.36%（3.22，7.50）。另一方面，运动障碍型脑瘫占10.88%（6.26，15.49）。约32.10%（19.25，44.95）的病例为双侧，25.17%（16.84，33.50）为单侧。非洲地区脑瘫的发病率超过了发达国家报告的发病率。痉挛型和四肢瘫型亚型是最常见的。建议将举措导向对预防措施、早期检测策略和综合管理方案的战略关注。
