Krishnan M M, Lath N K, Govind A
Ann Ophthalmol. 1985 Apr;17(4):253-7.
A prospective controlled trial of topical 0.1% dexamethasone drops was undertaken with the purpose of determining its efficacy in the prevention of aphakic macular edema. Of the 56 eyes studied specifically at the second and sixth postoperative weeks, none of the 28 in the steroid group showed macular edema, whereas the incidence in the nonsteroid group was 17.1% (P less than .01). The study highlights the role of steroids in reducing the incidence of postoperative macular as well as corneal edema. On the basis of earlier evidence and our observations on the conjunctival hyperfluorescence, the hypothesis for the genesis of macular edema has been modified.
进行了一项前瞻性对照试验，使用0.1%的地塞米松滴眼液，目的是确定其预防无晶状体性黄斑水肿的疗效。在专门于术后第二周和第六周研究的56只眼中，类固醇组的28只眼中无一例出现黄斑水肿，而非类固醇组的发生率为17.1%（P<0.01）。该研究突出了类固醇在降低术后黄斑水肿以及角膜水肿发生率方面的作用。基于早期证据以及我们对结膜高荧光的观察，黄斑水肿发生机制的假说已得到修正。
