Lemoine R, Gouyette A
Cancer Treat Rep. 1979 Aug;63(8):1335-41.
Using high-performance liquid chromatography, the stability of RFCNU was monitored as a function of pH in aqueous buffers at 37 degrees C and as a function of temperature in plasma. The kinetics of degradation of RFCNU are apparently first-order. The log kappa-pH profile demonstrated the hydroxyl ion-catalyzed solvolysis and a maximum stability around pH 3.0. This analytic assay was reliable for quantitating intact RFCNU in biologic fluids. After administration of 400 mg of RFCNU orally to a female patient, no intact drug was excreted in the urine and plasma levels were very low.
使用高效液相色谱法，在37℃的水性缓冲液中监测RFCNU的稳定性与pH的关系，以及在血浆中监测其稳定性与温度的关系。RFCNU的降解动力学显然是一级的。log kappa-pH曲线表明存在氢氧根离子催化的溶剂解作用，且在pH 3.0左右具有最大稳定性。该分析方法对于定量生物流体中的完整RFCNU是可靠的。在一名女性患者口服400 mg RFCNU后，尿液中未排出完整药物，血浆水平非常低。
