Department of Thyroid Surgery, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, Add: No. 63 Huangtang Road, Meijiang District, Meizhou, China.
Department of Radiology, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, Meizhou, China.
World J Surg Oncol. 2024 Jun 21;22(1):162. doi: 10.1186/s12957-024-03455-w.
The aim of this study is to investigate the risk factors for lateral cervical lymph node metastasis in papillary thyroid carcinoma (PTC).
Clinicopathological data (age, gender, Hashimoto's thyroiditis, preoperative circulating tumor cells (CTCs), multifocal, maximum lesion diameter, invaded capsule, T stage, and lymph node metastasis) of 830 PTC patients diagnosed and treated in Meizhou People's Hospital from June 2021 to April 2023 were collected. The related factors of lateral cervical lymph node metastasis were analyzed.
There were 334 (40.2%), and 103 (12.4%) PTC patients with central lymph node metastasis, and lateral cervical lymph node metastasis, respectively. Compared with patients without lateral cervical lymph node metastasis, PTC patients with lateral cervical lymph node metastasis had a higher proportion of multifocal, maximum lesion diameter > 1 cm, invaded capsule, T3-T4 stage. Regression logistic analysis showed that male (odds ratio (OR): 2.196, 95% confidence interval (CI): 1.279-3.769, p = 0.004), age < 55 years old (OR: 2.057, 95% CI: 1.062-3.988, p = 0.033), multifocal (OR: 2.759, 95% CI: 1.708-4.458, p < 0.001), maximum lesion diameter > 1 cm (OR: 5.408, 95% CI: 3.233-9.046, p < 0.001), T3-T4 stage (OR: 2.396, 95% CI: 1.241-4.626, p = 0.009), and invaded capsule (OR: 2.051, 95% CI: 1.208-3.480, p = 0.008) were associated with lateral cervical lymph node metastasis.
Male, age < 55 years old, multifocal, maximum lesion diameter > 1 cm, T3-T4 stage, and invaded capsule were independent risk factors for lateral cervical lymph node metastasis in PTC.
本研究旨在探讨甲状腺乳头状癌（PTC）颈侧淋巴结转移的危险因素。
收集 2021 年 6 月至 2023 年 4 月在梅州市人民医院诊断和治疗的 830 例 PTC 患者的临床病理资料（年龄、性别、桥本甲状腺炎、术前循环肿瘤细胞（CTC）、多灶性、最大病变直径、包膜侵犯、T 分期和淋巴结转移）。分析颈侧淋巴结转移的相关因素。
830 例 PTC 患者中，中央淋巴结转移 334 例（40.2%），颈侧淋巴结转移 103 例（12.4%）。与无颈侧淋巴结转移的 PTC 患者相比，有颈侧淋巴结转移的 PTC 患者多为多灶性、最大病变直径＞1cm、包膜侵犯、T3-T4 期。回归逻辑分析显示，男性（比值比（OR）：2.196，95%置信区间（CI）：1.279-3.769，p=0.004）、年龄＜55 岁（OR：2.057，95%CI：1.062-3.988，p=0.033）、多灶性（OR：2.759，95%CI：1.708-4.458，p＜0.001）、最大病变直径＞1cm（OR：5.408，95%CI：3.233-9.046，p＜0.001）、T3-T4 期（OR：2.396，95%CI：1.241-4.626，p=0.009）和包膜侵犯（OR：2.051，95%CI：1.208-3.480，p=0.008）与颈侧淋巴结转移有关。
男性、年龄＜55 岁、多灶性、最大病变直径＞1cm、T3-T4 期和包膜侵犯是 PTC 颈侧淋巴结转移的独立危险因素。
