Aix Marseille Univ, Université de Toulon, CNRS, CPT (UMR 7332), Turing Centre for Living systems, Marseille, France.
Laboratoire Physico-Chimie Curie, UMR 168, Institut Curie, PSL Research University, CNRS, Sorbonne Université, 75005 Paris, France.
Phys Rev E. 2024 May;109(5-1):054406. doi: 10.1103/PhysRevE.109.054406.
Cell adhesion proteins typically form stable clusters that anchor the cell membrane to its environment. Several works have suggested that cell membrane protein clusters can emerge from a local feedback between the membrane curvature and the density of proteins. Here, we investigate the effect of such a curvature-sensing mechanism in the context of cell adhesion proteins. We show how clustering emerges in an intermediate range of adhesion and curvature-sensing strengths. We identify key differences with the tilt-induced gradient sensing mechanism we previously proposed (Lin et al., arXiv:2307.03670).
细胞黏附蛋白通常形成稳定的簇，将细胞膜固定在其环境中。有几项研究表明，细胞膜蛋白簇可以从膜曲率和蛋白密度之间的局部反馈中产生。在这里，我们研究了这种曲率感应机制在细胞黏附蛋白中的作用。我们展示了在中等黏附和曲率感应强度范围内聚类是如何出现的。我们发现了与我们之前提出的倾斜感应梯度感应机制（Lin 等人，arXiv：2307.03670）的关键差异。
