Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Methods Mol Biol. 2024;2809:67-75. doi: 10.1007/978-1-0716-3874-3_4.
HLA allele information is essential for a variety of medical applications, such as genomic studies of multifactorial diseases, including immune system and inflammation-related disorders, and donor selection in organ transplantation and regenerative medicine. To obtain this information, an accurate HLA typing method that is applicable for any allele registered in HLA allele databases is needed. Here we describe a method-called HLA-HD-for determining alleles from a current HLA database using next-generation sequencing (NGS) results.
HLA 等位基因信息对于各种医疗应用至关重要，例如多因素疾病的基因组研究，包括免疫系统和炎症相关疾病，以及器官移植和再生医学中的供体选择。为了获得此信息，需要一种适用于 HLA 等位基因数据库中注册的任何等位基因的准确 HLA 分型方法。在这里，我们描述了一种方法，称为 HLA-HD，用于使用下一代测序 (NGS) 结果从当前 HLA 数据库中确定等位基因。
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