人体药物的胃肠道吸收：当前概念与研究方法综述
The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation.
作者信息
Hirtz J
出版信息
Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):77S-83S. doi: 10.1111/j.1365-2125.1985.tb02746.x.
Abstract
The various mechanisms which have been advanced to explain drug absorption are critically reviewed and the limitations of current theories are discussed. Various techniques for investigating drug absorption and transit through the gut are presented, and the results obtained with metoprolol are briefly considered to illustrate the potential of some of these methods.
摘要
对已提出的用于解释药物吸收的各种机制进行了批判性综述，并讨论了当前理论的局限性。介绍了研究药物在肠道吸收和转运的各种技术，并简要考虑了用美托洛尔获得的结果，以说明其中一些方法的潜力。
相似文献
1
The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation.人体药物的胃肠道吸收：当前概念与研究方法综述
Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):77S-83S. doi: 10.1111/j.1365-2125.1985.tb02746.x.
2
Evaluation of oxprenolol and metoprolol Oros systems in the dog: comparison of in vivo and in vitro drug release, and of drug absorption from duodenal and colonic infusion sites.犬体内氧烯洛尔和美托洛尔渗透泵系统的评价：体内外药物释放及十二指肠和结肠输注部位药物吸收的比较
Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):91S-95S. doi: 10.1111/j.1365-2125.1985.tb02748.x.
3
Gastric and intestinal absorption of oxprenolol in humans.氧烯洛尔在人体胃肠道的吸收情况。
J Clin Pharmacol. 1986 Nov-Dec;26(8):611-5. doi: 10.1002/j.1552-4604.1986.tb02958.x.
4
Investigation of drug absorption from the gastrointestinal tract of man. IV. Influence of food and digestive secretions on metoprolol jejunal absorption.人体胃肠道药物吸收的研究。IV. 食物和消化液对美托洛尔空肠吸收的影响。
Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):119S-125S. doi: 10.1111/j.1365-2125.1985.tb02752.x.
5
Gastrointestinal transit of Oros drug delivery systems in healthy volunteers: a short report.健康志愿者中口服药物递送系统的胃肠道转运：简短报告
Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):203S-206S. doi: 10.1111/j.1365-2125.1985.tb02763.x.
6
Investigation of drug absorption from the gastrointestinal tract of man. I. Metoprolol in the stomach, duodenum and jejunum.人体胃肠道药物吸收的研究。I. 美托洛尔在胃、十二指肠和空肠中的情况。
Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):97S-105S. doi: 10.1111/j.1365-2125.1985.tb02749.x.
7
Investigation of drug absorption from the gastrointestinal tract of man. II. Metoprolol in the jejunum and ileum.人体胃肠道药物吸收的研究。II. 美托洛尔在空肠和回肠的吸收情况
Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):107S-112S. doi: 10.1111/j.1365-2125.1985.tb02750.x.
8
The effect of spinal analgesia and surgery on peroperative drug absorption and gastric emptying in man.
Acta Anaesthesiol Scand. 1987 Feb;31(2):165-7. doi: 10.1111/j.1399-6576.1987.tb02542.x.
9
Physiologic considerations in drug absorption from the gastrointestinal tract.药物从胃肠道吸收的生理学考量
J Allergy Clin Immunol. 1986 Oct;78(4 Pt 2):689-94. doi: 10.1016/0091-6749(86)90047-3.
10
Drug absorption in gastrointestinal disease with particular reference to malabsorption syndromes.胃肠道疾病中的药物吸收，特别涉及吸收不良综合征。
Clin Pharmacokinet. 1977 Jan-Feb;2(1):45-60. doi: 10.2165/00003088-197702010-00004.
引用本文的文献
1
Mechanistic modeling of gastrointestinal motility with integrated dissolution for simulating drug absorption.用于模拟药物吸收的胃肠道蠕动与溶出整合的机制模型
ADMET DMPK. 2020 Jun 9;8(3):314-324. doi: 10.5599/admet.829. eCollection 2020.
2
Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals.基于生理学的药代动力学-定量系统毒理学和安全性 (PBPK-QSTS) 建模方法应用于预测阿米替林在人群和个体中的药代动力学变异性和心脏安全性。
J Pharmacokinet Pharmacodyn. 2018 Oct;45(5):663-677. doi: 10.1007/s10928-018-9597-6. Epub 2018 Jun 25.
3
A Review of Food-Drug Interactions on Oral Drug Absorption.食物-药物相互作用对口服药物吸收的影响综述
Drugs. 2017 Nov;77(17):1833-1855. doi: 10.1007/s40265-017-0832-z.
4
Oral bioavailability: issues and solutions via nanoformulations.口服生物利用度：通过纳米制剂解决的问题与方案
Clin Pharmacokinet. 2015 Apr;54(4):325-57. doi: 10.1007/s40262-015-0242-x.
5
Data mining in the U.S. National Toxicology Program (NTP) database reveals a potential bias regarding liver tumors in rodents irrespective of the test agent.对美国国家毒理学计划（NTP）数据库进行数据挖掘后发现，无论测试剂为何，啮齿动物肝脏肿瘤存在潜在偏差。
PLoS One. 2015 Feb 6;10(2):e0116488. doi: 10.1371/journal.pone.0116488. eCollection 2015.
6
Helicobacter pylori infection and drugs malabsorption.幽门螺杆菌感染与药物吸收不良。
World J Gastroenterol. 2014 Aug 14;20(30):10331-7. doi: 10.3748/wjg.v20.i30.10331.
7
G.L. Amidon, H. Lennernas, V.P. Shah, and J.R. Crison. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability, Pharm Res 12, 413-420, 1995--backstory of BCS.G.L. 阿米顿、H. 伦纳纳斯、V.P. 沙阿和J.R. 克里森。生物药剂学药物分类的理论基础：体外药物产品溶出度与体内生物利用度的相关性，《药物研究》12卷，413 - 420页，1995年——生物药剂学分类系统的背景故事
AAPS J. 2014 Sep;16(5):894-8. doi: 10.1208/s12248-014-9620-9. Epub 2014 Jun 25.
8
A mechanism-based approach for absorption modeling: the Gastro-Intestinal Transit Time (GITT) model.基于机制的吸收建模方法：胃肠传输时间（GITT）模型。
AAPS J. 2012 Jun;14(2):155-63. doi: 10.1208/s12248-012-9324-y.
9
10
Floating drug delivery of nevirapine as a gastroretentive system.奈韦拉平的胃滞留型漂浮给药系统
J Young Pharm. 2010 Oct;2(4):350-5. doi: 10.4103/0975-1483.71622.
本文引用的文献
1
An evaluation of indium DTPA chelate in the measurement of gastric emptying by scintiscanning.铟 DTPA 螯合物在闪烁扫描法测定胃排空中的评价。
Gut. 1971 Aug;12(8):611-5. doi: 10.1136/gut.12.8.611.
2
The alimentary tract.消化道。
Annu Rev Physiol. 1960;22:381-406. doi: 10.1146/annurev.ph.22.030160.002121.
3
Per cent absorbed time plots derived from blood level and/or urinary excretion data.根据血药浓度和/或尿排泄数据得出的吸收百分比-时间曲线图。
J Pharm Sci. 1963 Jun;52:610-1. doi: 10.1002/jps.2600520629.
4
The influence of experimental procedures and dose on the intestinal absorption of an onium compound, benzomethamine.实验程序和剂量对一种鎓化合物苯甲胺肠道吸收的影响。
J Pharmacol Exp Ther. 1961 Mar;131:319-27.
5
On the mechanism of intestinal absorption of drugs.论药物的肠道吸收机制。
J Pharmacol Exp Ther. 1959 Apr;125(4):275-82.
6
Studies of intestinal digestion and absorption in the human.人体肠道消化与吸收的研究。
J Clin Invest. 1957 Oct;36(10):1521-36. doi: 10.1172/JCI103549.
7
Ion and water fluxes in the ileum of rats.大鼠回肠中的离子和水通量
J Gen Physiol. 1957 Sep 20;41(1):143-68. doi: 10.1085/jgp.41.1.143.
8
The gastric secretion of drugs: a pH partition hypothesis.药物的胃分泌：pH分配假说
J Pharmacol Exp Ther. 1957 Mar;119(3):361-9.
9
An incremental method for the study of the absorption of drugs whose kinetics are described by a two-compartment model: estimation of the microscopic rate constants.
J Pharmacokinet Biopharm. 1983 Aug;11(4):401-24. doi: 10.1007/BF01058958.
10
New method for calculating the intrinsic absorption rate of drugs.计算药物内在吸收速率的新方法。
J Pharm Sci. 1968 Jun;57(6):918-28. doi: 10.1002/jps.2600570602.
Zotero 插件