Read N G, Radomski M W, Goodwin D A, Moncada S
Br J Haematol. 1985 Jun;60(2):305-14. doi: 10.1111/j.1365-2141.1985.tb07416.x.
The morphology of washed human platelets stored at 4 degrees C has been examined over a period of 96 h. Platelets prepared using prostacyclin showed good preservation of their internal structure. These platelets showed no signs of activation when stirred in an aggregometer and only small reversible aggregates were formed during storage. In contrast, platelets prepared using a more conventional method, which does not use prostacyclin, showed poor preservation of internal structure. Storage and stirring of these platelets resulted in activation and morphological deterioration. These observations support our previous finding that prostacyclin prolongs the viability of washed human platelets in vitro.
在96小时的时间段内，对储存在4摄氏度的洗涤过的人血小板的形态进行了检查。使用前列环素制备的血小板其内部结构保存良好。这些血小板在聚集仪中搅拌时没有激活迹象，并且在储存期间仅形成小的可逆聚集体。相比之下，使用更传统方法（不使用前列环素）制备的血小板内部结构保存不佳。这些血小板的储存和搅拌导致激活和形态恶化。这些观察结果支持了我们之前的发现，即前列环素可延长洗涤过的人血小板在体外的存活期。
