Center for Reproductive Sciences, Department of Obstetrics and Gynecology, University of California San Francisco, San Francisco, CA, 94143, USA.
Center for Reproductive Sciences, Department of Obstetrics and Gynecology, University of California San Francisco, San Francisco, CA, 94143, USA.
Biochem Biophys Res Commun. 2024 Sep 24;726:150256. doi: 10.1016/j.bbrc.2024.150256. Epub 2024 Jun 12.
Understanding of embryonic development has led to the clinical application of Assisted Reproductive technologies (ART), with the resulting birth of millions of children. Recent developments in metabolomics, proteomics, and transcriptomics have brought to light new insights into embryonic growth dynamics, with implications spanning reproductive medicine, stem cell research, and regenerative medicine. The review explores the key metabolic processes and molecular pathways active during preimplantation embryo development, including PI3K-Akt, mTOR, AMPK, Wnt/β-catenin, TGF-β, Notch and Jak-Stat signaling pathways. We focused on analyzing the differences occurring in vitro as opposed to in vivo development and we discussed significant physiological and clinical implications.
对胚胎发育的认识导致了辅助生殖技术（ART）的临床应用，由此诞生了数百万计的儿童。代谢组学、蛋白质组学和转录组学的最新进展揭示了胚胎生长动态的新见解，其影响涵盖生殖医学、干细胞研究和再生医学。本文综述了胚胎植入前发育过程中关键的代谢过程和分子途径，包括 PI3K-Akt、mTOR、AMPK、Wnt/β-catenin、TGF-β、Notch 和 Jak-Stat 信号通路。我们重点分析了体外和体内发育过程中的差异，并讨论了其重要的生理和临床意义。
