阻断C1区的胆碱能受体会消除腹外侧延髓A1区对阿片类药物的高血压反应。

Blockade of cholinergic receptors in the C1 area abolishes hypertensive response to opiates in the A1 area of the ventrolateral medulla.

作者信息

Punnen S, Sapru H N

出版信息

Brain Res. 1985 Jun 10;336(1):180-6. doi: 10.1016/0006-8993(85)90433-0.

Abstract

Opiate receptor stimulation by microinjections of a delta-receptor agonist, D-Ala2-D-Leu5-enkephalin (DADLE) into the caudal depressor (A1) area of the ventrolateral medulla produced a hypertensive response which was prevented as well as reversed by the blockade of cholinergic receptors in the rostral pressor (C1) area. These results suggest that the hypertensive responses to opiates in the A1 area are mediated via cholinergic mechanisms in the rostral C1 area of the ventrolateral medulla and acetylcholine may be the neurotransmitter released in the ventrolateral pressor area.

摘要

通过向延髓腹外侧尾侧降压（A1）区域微量注射δ受体激动剂D - 丙氨酸2 - D - 亮氨酸5 - 脑啡肽（DADLE）刺激阿片受体，会产生高血压反应，而通过阻断延髓腹外侧头侧升压（C1）区域的胆碱能受体可预防并逆转这种反应。这些结果表明，A1区域对阿片类药物的高血压反应是通过延髓腹外侧头侧C1区域的胆碱能机制介导的，乙酰胆碱可能是腹外侧升压区域释放的神经递质。