Interdisciplinary Research Center in Biomedical Materials (IRCBM), COMSATS University Islamabad, Lahore Campus, 1.5 KM defense Road Off Raiwand Road Lahore, Pakistan.
São Carlos Institute of Chemistry, University of São Paulo, São Carlos, SP 13560-970, Brazil.
Chem Commun (Camb). 2024 Jul 9;60(56):7212-7215. doi: 10.1039/d4cc01320d.
A label-free one-step lithographically masked deposition technique was implemented for the fabrication of gold nanoparticle (Au NP) micropatterns. These micropatterns serve as active substrates for surface-enhanced infrared absorption spectroscopy (SEIRAS) and exhibit a substantial increase in the IR signal upon adsorption of multiple proteins compared to untreated surfaces. Micro-FTIR chemical imaging was conducted to evaluate the efficacy of Au NP micropatterns as singular enhancers for SEIRAS across diverse IR-active substrates demonstrating a promising application for the detection of proteins at low concentrations within biological fluids.
一种无标记的一步光刻掩模沉积技术被用于制造金纳米粒子（Au NP）微图案。这些微图案作为表面增强红外吸收光谱（SEIRAS）的活性衬底，与未处理的表面相比，在吸附多个蛋白质后，IR 信号有显著增强。微傅里叶变换红外化学成像用于评估 Au NP 微图案作为 SEIRAS 的单一增强剂在不同的 IR 活性衬底上的效果，为在生物流体中低浓度蛋白质的检测提供了有前途的应用。
