Margolin K A, Pak H Y, Esensten M L, Doroshow J H
Cancer. 1985 Aug 1;56(3):691-5. doi: 10.1002/1097-0142(19850801)56:3<691::aid-cncr2820560342>3.0.co;2-q.
Hepatic metastases occur rarely in epithelial ovarian carcinoma and also appear to be unusual in malignant stromal tumors of the ovary (granulosa cell tumors). Recently two patients with extensive hepatic metastasis from this primary tumor, were treated. Review of the experience at the City of Hope National Medical Center provided three additional patients with a confirmed diagnosis of granulosa cell tumor of the ovary, one of whom is alive and disease-free. A review of clinical and pathologic data revealed that both of the other patients died of their disease and had hepatic metastases proven at autopsy. Hemorrhagic events complicating the clinical course of these patients were frequent. It is believed that the frequency of hepatic metastasis in granulosa cell tumor of the ovary may be higher than has been appreciated in the past, and that the cystic-hemorrhagic nature of these lesions contributes to the morbidity and mortality associated with granulosa cell tumors of the ovary.
肝转移在卵巢上皮性癌中很少见，在卵巢恶性间质瘤（颗粒细胞瘤）中似乎也不常见。最近，两名患有这种原发性肿瘤广泛肝转移的患者接受了治疗。回顾希望之城国家医疗中心的经验，又发现了另外三名确诊为卵巢颗粒细胞瘤的患者，其中一人存活且无疾病。对临床和病理数据的回顾显示，另外两名患者均死于该疾病，尸检证实有肝转移。这些患者临床病程中并发的出血事件很常见。据信，卵巢颗粒细胞瘤中肝转移的发生率可能比过去认为的要高，并且这些病变的囊性出血性质导致了与卵巢颗粒细胞瘤相关的发病率和死亡率。
