Koc Nermin, Arinkan Sevcan Arzu, Sonmez Cansu, Kaya Berker
Department of Pathology, Haydarpasa Numune Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Department of Obstetrics and Gynecology, Central Hospital, Kristianstad, Sweden.
Fetal Pediatr Pathol. 2024 Jul-Aug;43(4):290-299. doi: 10.1080/15513815.2024.2368579. Epub 2024 Jun 24.
We investigated the role of E-cadherin and Ber-EP4 in tubal pregnancy by comparing their expressions in epithelial and trophoblastic cells both in ectopic tubal and intrauterine pregnancies. The Formalin-fixed paraffin embedded blocks of 17 intrauterine and 17 tubal pregnancies were immunohistochemically stained with E-cadherin and Ber-EP4. E-cadherin was expressed in the epithelium, villous and extravillous trophoblast in tubal and intrauterine pregnancies but not in the syncytiotrophoblast. The staining intensity was lower in the extra-villous trophoblast in tubal ectopic pregnancies compared with intrauterine pregnancies. Ber-EP4 was expressed in the epithelium of tubal and intrauterine pregnancies and only in villous cytotrophoblast. The intensity of staining in tubal pregnancy was higher than in intrauterine pregnancy. The loss of E-cadherin expression in extra-villous trophoblast and increased expression of Ber-EP4 in the villous cytotrophoblast may play a role in the formation of tubal pregnancy by allowing the blastocyst to attach to the tubal epithelium.
我们通过比较E-钙黏蛋白和Ber-EP4在异位输卵管妊娠和宫内妊娠的上皮细胞及滋养层细胞中的表达，研究了它们在输卵管妊娠中的作用。对17例宫内妊娠和17例输卵管妊娠的福尔马林固定石蜡包埋组织块进行E-钙黏蛋白和Ber-EP4免疫组织化学染色。E-钙黏蛋白在输卵管妊娠和宫内妊娠的上皮、绒毛及绒毛外滋养层中表达，但在合体滋养层中不表达。与宫内妊娠相比，输卵管异位妊娠的绒毛外滋养层染色强度较低。Ber-EP4在输卵管妊娠和宫内妊娠的上皮中表达，且仅在绒毛细胞滋养层中表达。输卵管妊娠的染色强度高于宫内妊娠。绒毛外滋养层中E-钙黏蛋白表达缺失以及绒毛细胞滋养层中Ber-EP4表达增加，可能通过使胚泡附着于输卵管上皮而在输卵管妊娠的形成中发挥作用。
