Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Anesthesiology and Surgical Oncology Research Group (ASORG), Houston, TX 77030, USA.
Curr Oncol. 2024 May 30;31(6):3086-3098. doi: 10.3390/curroncol31060235.
Pain is one of the most common symptoms in patients with cancer. Pain not only negatively affects the quality of life of patients with cancer, but it has also been associated with reduced survival. Pain management is therefore a critical component of cancer care. Prescription opioids remain the first-line approach for the management of moderate-to-severe pain associated with cancer. However, there has been increasing interest in understanding whether these analgesics could impact cancer progression. Furthermore, epidemiological data link a possible association between prescription opioid usage and cancer development. Until more robust evidence is available, patients with cancer with moderate-to-severe pain may receive opioids to decrease suffering. However, future studies should be conducted to evaluate the role of opioids and opioid receptors in specific cancers.
疼痛是癌症患者最常见的症状之一。疼痛不仅会对癌症患者的生活质量产生负面影响，而且还与生存率降低有关。因此，疼痛管理是癌症治疗的关键组成部分。处方类阿片类药物仍然是治疗与癌症相关的中重度疼痛的一线方法。然而，人们越来越关注这些阿片类药物是否会影响癌症的进展。此外，流行病学数据表明，处方类阿片类药物的使用与癌症的发生之间可能存在关联。在更有力的证据出现之前，患有中重度疼痛的癌症患者可能会接受阿片类药物来减轻痛苦。然而，未来应该进行更多的研究来评估阿片类药物和阿片类受体在特定癌症中的作用。
