Miller J B, Smith M R, Boyer D S
Arch Ophthalmol. 1979 Nov;97(11):2123-7. doi: 10.1001/archopht.1979.01020020441005.
Carbon dioxide laser photocautery was used successfully intraocularly in human patients to seal fibrovascular fronds and retinal tears at the time of vitrectomy. Closure of rubeotic vessels in the iris was demonstrated histologically. The 10.6-microgram infrared radiation was delivered to the intraocular treatment site by means of 1.5-mm-diameter photocautery probe containing a 1.0-mm-diameter lumen closed at the end with an infrared transmitting window. Treatment was localized to the tissue adjacent to the window. Typical energy dosage was 0.4 W for 2 to 4 s duration. These early clinical trials were carried out under the guidelines established by the Food and Drug Administration; informed consent clearly outlined the experimental nature of these studies.
二氧化碳激光光凝术已成功应用于人类患者的眼内，在玻璃体切除术中封闭纤维血管襻和视网膜裂孔。组织学证实虹膜新生血管已闭合。10.6微米的红外辐射通过一个直径1.5毫米的光凝探头传递到眼内治疗部位，该探头有一个直径1.0毫米的管腔，末端用红外透射窗封闭。治疗局限于靠近窗口的组织。典型的能量剂量为0.4瓦，持续2至4秒。这些早期临床试验是在食品药品监督管理局制定的指导方针下进行的；知情同意书明确概述了这些研究的实验性质。
