Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
J Immunol. 2024 Aug 15;213(4):519-525. doi: 10.4049/jimmunol.2300815.
Stroke is one of the leading causes of death and long-term disabilities worldwide. In addition to interruption of blood flow, inflammation is widely recognized as an important factor mediating tissue destruction in stroke. Depending on their phenotype, microglia, the main leukocytes in the CNS, are capable of either causing further tissue damage or promoting brain restoration after stroke. β2-integrins are cell adhesion molecules that are constitutively expressed on microglia. The function of β2-integrins has been investigated extensively in animal models of ischemic stroke, but their role in hemorrhagic stroke is currently poorly understood. We show in this study that dysfunction of β2-integrins is associated with improved functional outcome and decreased inflammatory cytokine expression in the brain in a mouse model of hemorrhagic stroke. Furthermore, β2-integrins affect microglial phenotype and cytokine responses in vivo. Therefore, our findings suggest that targeting β2-integrins in hemorrhagic stroke may be beneficial.
中风是全球范围内导致死亡和长期残疾的主要原因之一。除了血流中断外，炎症被广泛认为是介导中风组织破坏的重要因素。小胶质细胞是中枢神经系统中的主要白细胞，根据其表型，小胶质细胞能够导致进一步的组织损伤，也能够促进中风后的大脑恢复。β2 整合素是细胞黏附分子，在小胶质细胞上持续表达。β2 整合素的功能已在缺血性中风的动物模型中得到广泛研究，但它们在出血性中风中的作用目前知之甚少。我们在本研究中表明，在出血性中风小鼠模型中，β2 整合素功能障碍与改善的功能结果和减少的脑内炎症细胞因子表达有关。此外，β2 整合素影响体内小胶质细胞表型和细胞因子反应。因此，我们的研究结果表明，针对出血性中风中的β2 整合素可能是有益的。
