Li Yixuan, Niu Jingyi, Liu Yiyu, Dai Yu, Ni Hongbo, Wang Jinliang, Fang Rendong, Ye Chao
Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China.
College of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.
Vet Sci. 2024 Jun 2;11(6):248. doi: 10.3390/vetsci11060248.
In recent years, the clinical cases of ENTV-2 infection have increased and become prevalent in several provinces of China. In this study, we reported the occurrence of ENTV-2 in one goat farm in Chongqing, southwest China. The complete genome of an emerged ENTV-2 isolate (designated as CQ2) was sequenced with 7468 bp in length. Phylogenetic analysis revealed that ENTV-2 consisted of two main lineages. Lineage 1 was composed of Chinese strains and could be subdivided into five sublineages. CQ2 and the other six recent isolates from China were clustered in sublineage 1.5; however, CQ2 was significantly different from the other six isolates. Furthermore, recombination analysis suggested that CQ2 might be a recombinant variant derived from sublineage 1.5 and sublineage 1.2 strains, with the recombination region in areas of and genes. In conclusion, we sequenced and analyzed the complete genome of a potential ENTV-2 recombinant, which may contribute to our understanding of the genetic variation and evolution of ENTV-2 in China.
近年来，ENTV - 2感染的临床病例有所增加，并在中国多个省份流行。在本研究中，我们报告了中国西南部重庆市一个山羊场中ENTV - 2的出现情况。对一株新出现的ENTV - 2分离株（命名为CQ2）的全基因组进行了测序，其长度为7468 bp。系统发育分析表明，ENTV - 2由两个主要谱系组成。谱系1由中国菌株组成，可细分为五个亚谱系。CQ2和其他六株来自中国的近期分离株聚集在亚谱系1.5中；然而，CQ2与其他六株分离株有显著差异。此外，重组分析表明，CQ2可能是源自亚谱系1.5和亚谱系1.2菌株的重组变体，重组区域位于 和 基因区域。总之，我们对一株潜在的ENTV - 2重组体的全基因组进行了测序和分析，这可能有助于我们了解中国ENTV - 2的遗传变异和进化情况。
Zotero 插件
