Hu Yabin, Yang Guiyan, Wang Dan, Gu Wangyang, Xie Dan, Huang Tingyue, Xue Peng, Tang Jingyi, Wei Hui, Li Shenghui, Tong Shilu, Liu Shijian
Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya 572022, China.
Department of Clinical Epidemiology and Biostatistics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Toxics. 2024 May 27;12(6):392. doi: 10.3390/toxics12060392.
Insecticide exposure may affect childhood asthma/wheezing, but evidence is scarce in low- and middle-income countries. We conducted a population-based cross-sectional study in Sanya, China. Generalized linear models were adopted to assess the associations of insecticide exposure with childhood asthma/wheezing, reported as odds ratios (ORs) and 95% confidence intervals (CIs). A subgroup analysis was performed to explore the possible effects of sociodemographic and environmental factors on these associations. The median age of the 9754 children was 6.7 years, and 5345 (54.8%) were boys. The prevalences of ever asthma (EA), ever wheezing (EW), and current wheezing (CW) were 7.4%, 5.3%, and 2.9%, respectively. We found a greater prevalence of childhood EA with insecticide exposure (OR = 1.18, 95% CI: 1.00, 1.38). Outdoor insecticide exposure was associated with elevated ORs for EA (1.24, 95% CI: 1.03, 1.50), EW (1.27, 95% CI: 1.03, 1.57), and CW (1.38, 95% CI: 1.04, 1.81). The for the trend in insecticide exposure frequency was significant for EA ( = 0.001) and CW ( = 0.034). These adverse impacts were pronounced in girls who were exposed to low temperatures. Our findings suggest adverse effects of insecticide use, especially outdoors, on childhood asthma/wheezing. Further studies are warranted to verify this association and develop tailored prevention measures.
接触杀虫剂可能会影响儿童哮喘/喘息，但在低收入和中等收入国家，相关证据很少。我们在中国三亚开展了一项基于人群的横断面研究。采用广义线性模型评估杀虫剂接触与儿童哮喘/喘息之间的关联，以比值比（OR）和95%置信区间（CI）表示。进行了亚组分析，以探讨社会人口学和环境因素对这些关联的可能影响。9754名儿童的中位年龄为6.7岁，其中5345名（54.8%）为男孩。曾经患哮喘（EA）、曾经喘息（EW）和当前喘息（CW）的患病率分别为7.4%、5.3%和2.9%。我们发现接触杀虫剂的儿童患EA的患病率更高（OR = 1.18，95% CI：1.00，1.38）。户外接触杀虫剂与EA（1.24，95% CI：1.03，1.50）、EW（1.27，95% CI：1.03，1.57）和CW（1.38，95% CI：1.04，1.81）的OR升高有关。杀虫剂接触频率趋势对EA（ = 0.001）和CW（ = 0.034）具有显著意义。这些不利影响在暴露于低温的女孩中更为明显。我们的研究结果表明，使用杀虫剂，尤其是在户外使用，对儿童哮喘/喘息有不利影响。有必要进一步开展研究以验证这种关联并制定针对性的预防措施。
