Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
Genetics, Vaccines and Pediatric Infectious Diseases Research Group, Instituto de Investigación Sanitaria de Santiago, Universidad de Santiago, Santiago de Compostela, Spain.
Influenza Other Respir Viruses. 2024 Jun;18(6):e13341. doi: 10.1111/irv.13341.
Respiratory syncytial virus (RSV) and influenza infections cause significant annual morbidity and mortality worldwide in at-risk populations. This study is aimed at assessing hospital burden and healthcare resource utilization (HRU) of RSV and influenza in adults in Spain.
Data were obtained from the Projected Hospitalisation Database of inpatient episodes (ages: younger adults 18-50 and 51-64 years; older adults 65-74, 75-84, and ≥ 85 years) during 2015, 2017, and 2018 in Spanish public hospitals. Incidence, mean hospitalization, and HRU assessments, including length of stay (LOS), intensive care unit (ICU) usage, and age-standardized mortality rates, were collected and stratified by age group, with analyses focusing on the adult population (≥ 18 years old).
Mean hospitalization rate in the population across all years was lower in individuals with RSV versus influenza (7.2/100,000 vs. 49.7/100,000 individuals). ICU admissions and median LOS were similar by age group for both viruses. Age-standardized mortality was 6.3/100,000 individuals and 6.1/100,000 individuals in patients with RSV and influenza, respectively, and mortality rates were similar in older adults (≥ 65 years) for both viruses.
RSV and influenza infection were associated with considerable HRU. There is a substantial disease burden for RSV infection in older adults ≥ 65 years. While RSV hospitalization rates in adults reported here appeared lower than influenza, RSV is still underdiagnosed in the hospital setting and its incidence might be similar to, or higher than, influenza.
呼吸道合胞病毒（RSV）和流感感染在全球高危人群中造成了显著的年发病率和死亡率。本研究旨在评估西班牙成人中 RSV 和流感的医院负担和医疗资源利用（HRU）。
数据来自 2015 年、2017 年和 2018 年西班牙公立医院住院患者项目住院病例数据库（年龄：年轻成年人 18-50 岁和 51-64 岁；老年人 65-74 岁、75-84 岁和≥85 岁）。收集发病率、平均住院时间和 HRU 评估数据，包括住院时间（LOS）、重症监护病房（ICU）使用率和年龄标准化死亡率，并按年龄组分层，分析重点为成年人群（≥18 岁）。
所有年份人群中 RSV 的平均住院率低于流感（7.2/10 万与 49.7/10 万）。两种病毒的 ICU 入院率和中位 LOS 在各年龄段相似。RSV 和流感患者的年龄标准化死亡率分别为 6.3/10 万和 6.1/10 万，两种病毒在≥65 岁的老年人中的死亡率相似。
RSV 和流感感染与大量 HRU 相关。≥65 岁的老年人 RSV 感染负担很大。虽然这里报告的成人 RSV 住院率似乎低于流感，但 RSV 在医院环境中仍被漏诊，其发病率可能与流感相似，甚至高于流感。
