在丹麦高危和弹性研究中，与基于人群的对照组相比，11 岁患有精神分裂症或双相情感障碍家族高风险的儿童的炎症标志物、躯体抱怨、药物使用和医疗保健情况。
Inflammatory markers, somatic complaints, use of medication and health care in 11-year-old children at familial high risk of schizophrenia or bipolar disorder compared with population-based controls. The Danish High Risk and Resilience Study - via 11.
机构信息
Mental Health Centre Copenhagen, Copenhagen University Hospital, Mental Health Services, Capital Region of Denmark, Copenhagen, Denmark.
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
出版信息
Nord J Psychiatry. 2024 Aug;78(6):507-517. doi: 10.1080/08039488.2024.2369145. Epub 2024 Jun 26.
PURPOSE
Patients with schizophrenia or bipolar disorder are at increased risk of somatic illnesses and have more somatic complaints compared with the general population. Schizophrenia and bipolar disorder are highly heritable. Already during childhood, children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BD) are at increased risk of psychiatric disorders and cognitive and social impairments. Knowledge about physical conditions is sparse.
MATERIALS AND METHODS
Through blood tests ( = 293), interviews, and questionnaires, we assessed inflammatory markers, somatic complaints, medication - and health care use in 11-year-old children at FHR-SZ, FHR-BD, and population-based controls (PBC).
RESULTS
Children at FHR-SZ had higher concentrations of leucocytes (mean 6.41, 0.73) compared with PBC (mean 5.78, 0.27, = 0.005) and of neutrophilocytes (FHR-SZ: mean 3.11, 1.32, PBC: mean 2.70, 0.96, = 0.024). Compared with PBC (26.6%), more children at FHR-SZ (40.5%, = 0.007) reported somatic complaints. So did caregivers and teachers to children at FHR-BD. Somatic complaints, higher concentrations of leucocytes, and neutrophilocytes were associated with lower levels of physical activity. Children at FHR-BD with psychiatric disorders reported more somatic complaints compared with those without.
CONCLUSION
Children at FHR-SZ had higher concentrations of leucocytes and neutrophilocytes than PBC. Children at FHR-SZ or FHR-BP displayed more somatic complaints than controls. Our study highlights rarely explored disadvantage of being born to parents with schizophrenia or bipolar disorder. To enhance understanding of how physical conditions in childhood may interplay with later transition to mental disorders in children at FHR-SZ and FHR-BD, further research is needed.
目的
精神分裂症或双相情感障碍患者的躯体疾病风险增加，且与普通人群相比，他们有更多的躯体抱怨。精神分裂症和双相情感障碍的遗传性很强。在儿童时期，精神分裂症家族高风险（FHR-SZ）或双相情感障碍家族高风险（FHR-BD）的儿童就已经有更高的精神疾病和认知及社会障碍风险。目前对于身体状况的了解还很有限。
材料和方法
通过血液测试（ = 293）、访谈和问卷调查，我们评估了炎症标志物、躯体抱怨、药物使用和 11 岁 FHR-SZ、FHR-BD 和基于人群的对照组（PBC）儿童的医疗保健使用情况。
结果
与 PBC（平均 5.78，0.27， = 0.005）相比，FHR-SZ 儿童的白细胞浓度（平均 6.41，0.73）更高，与 PBC（平均 2.70，0.96， = 0.024）相比，中性粒细胞浓度更高。与 PBC（26.6%）相比，更多的 FHR-SZ 儿童（40.5%， = 0.007）报告有躯体抱怨。FHR-BD 的儿童及其照顾者和教师也是如此。躯体抱怨、白细胞和中性粒细胞浓度较高与较低的身体活动水平有关。与无精神障碍的 FHR-BD 儿童相比，有精神障碍的 FHR-BD 儿童报告更多的躯体抱怨。
结论
与 PBC 相比，FHR-SZ 儿童的白细胞和中性粒细胞浓度更高。与对照组相比，FHR-SZ 或 FHR-BP 的儿童有更多的躯体抱怨。我们的研究强调了出生于患有精神分裂症或双相情感障碍的父母的儿童所面临的罕见的劣势。为了增进对儿童时期身体状况如何与 FHR-SZ 和 FHR-BD 儿童后期向精神障碍过渡相互作用的理解，需要进一步的研究。
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