Begum Taslima, Arzmi Mohd Hafiz, Khatib Alfi, Uddin A B M Helal, Aisyah Abdullah Maryam, Rullah Kamal, Mat So'ad Siti Zaiton, Zulaikha Haspi Nur Fatihah, Nazira Sarian Murni, Parveen Humaira, Mukhtar Sayeed, Ahmed Qamar Uddin
Drug Discovery and Synthetic Chemistry Research Group, Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.
Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.
Nat Prod Res. 2025 Mar;39(6):1636-1652. doi: 10.1080/14786419.2024.2371564. Epub 2024 Jun 26.
Korth (kratom) is a tropical indigenous tree of Southeast Asia. It is commonly consumed by the people due to its various pharmacological properties. The leaves of this plant are traditionally used for the treatment of several diseases including pain, fever, cough, anxiety, depression, obesity, diarrhoea, wound healing, diabetes, hypertension as well as for the prevention of cancer and improvement of sexual performance. Phytochemical investigations have confirmed the presence of more than forty alkaloids along with the presence of other bioactive secondary metabolites. Among the alkaloids isolated, mitragynine and 7-hydroxymitragynine along with their derivatives have been widely evaluated and reported to possess various pharmacological effects. Hence, the aim of this review is to shed light on the traditional uses of kratom and the scientific studies to justify the folkloric claims and active principles responsible for the various medicinal effects associated with the leaves of this plant. This review highlights the potential benefits and toxicities associated with leaves along with the phytochemistry. Moreover, the existing gaps in the field of study have been identified along with the future directions to further avail the benefits of this plant species.
柯迪（ kratom ）是东南亚一种热带本土树木。由于其多种药理特性，它被人们广泛食用。这种植物的叶子传统上用于治疗多种疾病，包括疼痛、发烧、咳嗽、焦虑、抑郁、肥胖、腹泻、伤口愈合、糖尿病、高血压，还用于预防癌症和改善性功能。植物化学研究已证实其含有四十多种生物碱以及其他生物活性次生代谢产物。在分离出的生物碱中，帽柱木碱和 7-羟基帽柱木碱及其衍生物已得到广泛评估，并据报道具有多种药理作用。因此，本综述的目的是阐明柯迪的传统用途以及科学研究，以证明民间说法的合理性，并找出对该植物叶子的各种药用效果负责的活性成分。本综述强调了与叶子相关的潜在益处和毒性以及植物化学。此外，还确定了该研究领域中存在的差距以及未来进一步利用这种植物物种益处的方向。
