Department of Dermatology at Saint Georges Hospital University Medical Center, Faculty of Medicine and Medical Sciences, University of Balamand, Beirut, Lebanon.
Department of Family Medicine at Saint Georges Hospital University Medical Center, Faculty of Medicine and Medical Sciences, University of Balamand, Beirut, Lebanon.
Int J Dermatol. 2024 Oct;63(10):1334-1356. doi: 10.1111/ijd.17338. Epub 2024 Jun 25.
Acquired cutis laxa (ACL) is a rare, nonhereditary cutaneous disorder characterized by saggy inelastic skin. It has been associated with various inflammatory, autoimmune, and neoplastic diseases, in addition to certain infections and medication. This article reviews ACL the demographical, clinical, and histological features of ACL, focusing on all associated disorders. Additionally, this review article provides an in-depth discussion of all the mechanisms implicated in the pathogenesis of ACL and all therapeutic options available; we also present an algorithm for the workup of patients with ACL. A systematic literature review was performed on PubMed/Medline and EMBASE databases, searching for all available articles on ACL with no limits on participant age, race, sex, nationality, or publication date. Ninety-eight articles were included. The total number of included patients was 110, with a mean age of 36.4 years at presentation (range 0.25-78) and a M:F sex ratio of 1.24. ACL was most commonly associated with inflammatory disorders (43%) followed by neoplastic disorders (27%). In 73% of the neoplastic-associated cases, ACL occurred on average 2.4 years before malignancy onset. ACL occurs months to years after an underlying inflammatory disorder. In 10% of the cases, ACL was associated with a particular drug, and in 2%, it was associated with specific infections. Data were derived from case reports, case series, letters to editors, observational studies, and abstracts. Limitations include the accuracy of published data, potential patient selection, and reporting bias. Dermatologists should be alert to these associations to provide adequate screening and management of patients with ACL.
获得性皮肤松弛症（ACL）是一种罕见的非遗传性皮肤疾病，其特征为皮肤松弛、无弹性。它与各种炎症性、自身免疫性和肿瘤性疾病有关，此外还与某些感染和药物有关。本文回顾了 ACL 的人口统计学、临床和组织学特征，重点介绍了所有相关疾病。此外，本文还深入探讨了 ACL 发病机制中涉及的所有机制以及所有可用的治疗选择；我们还提出了一种用于 ACL 患者检查的算法。在 PubMed/Medline 和 EMBASE 数据库中进行了系统的文献复习，搜索了所有关于 ACL 的可用文章，对参与者的年龄、种族、性别、国籍或出版日期没有限制。共纳入 98 篇文章。纳入患者的总数为 110 例，平均发病年龄为 36.4 岁（范围为 0.25-78 岁），男女比例为 1.24。ACL 最常与炎症性疾病（43%）有关，其次是肿瘤性疾病（27%）。在 73%的肿瘤相关病例中，ACL 平均在恶性肿瘤发病前 2.4 年发生。ACL 发生在潜在炎症性疾病之后数月至数年。在 10%的病例中，ACL 与特定药物有关，在 2%的病例中，ACL 与特定感染有关。数据来源于病例报告、病例系列、给编辑的信件、观察性研究和摘要。局限性包括已发表数据的准确性、潜在的患者选择和报告偏倚。皮肤科医生应注意这些关联，以便为 ACL 患者提供充分的筛查和管理。
