Clinical Research Development Center, Motazedi Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Family Health Department, Tehran University of Medical Sciences, Tehran, Iran.
Reprod Health. 2024 Jun 26;21(1):91. doi: 10.1186/s12978-024-01833-x.
Endometriosis is a chronic and debilitating disease that can affect the entire reproductive life course of women, with potential adverse effects on pregnancy. The aim of the present study is to investigate the association between hypertensive disorders in pregnancy and endometriosis.
Relevant articles were searched from the Cochrane Library, PubMed, Scopus and Web of Science from inception up to December 2023. The full-text observational studies published in English that had a confirmed diagnosis of endometriosis were included. The case group included pregnant women diagnosed with endometriosis at any stage, while the control group consisted of pregnant women who had not been previously diagnosed with endometriosis. Two authors extracted and analyzed the data independently. Disagreements were reconciled by reviewing the full text by a third author. Endnote X9 was used for screening and data extraction. We used fixed and random effects models in Review Manager 5.3 to analyze the pooled data. The quality of the included studies was assessed using the Downs and Black checklist.
Out of the 9863 articles reviewed, 23 were selected for meta-analysis. According to the results of this study, there was an association between endometriosis and gestational hypertension (OR = 1.11, 95% CI: 1.06, 1.16; I = 45%, P < 0.00001; N = 8), pre-eclampsia (OR = 1.26, 95% CI: 1.18, 1.36; I = 37%, P < 0.00001; N = 12), and hypertensive disorders in pregnancy (OR = 1.13, 95% CI: 1.06, 1.21; I = 8%, P = 0.0001; N = 8).
This study confirmed that endometriosis may elevate the risk of developing gestational hypertensive disorders. Raising awareness of this issue will help to identify effective strategies for screening and early diagnosis of hypertensive disorders in pregnancy.
子宫内膜异位症是一种慢性且使人虚弱的疾病，可能会影响女性整个生殖生命过程，并对怀孕产生潜在的不良影响。本研究旨在探讨妊娠高血压疾病与子宫内膜异位症之间的关联。
从 Cochrane 图书馆、PubMed、Scopus 和 Web of Science 数据库中检索了截至 2023 年 12 月的相关文章。纳入的研究为已发表的英文全文观察性研究，且明确诊断为子宫内膜异位症。病例组包括在任何阶段被诊断为子宫内膜异位症的孕妇，而对照组则为之前未被诊断为子宫内膜异位症的孕妇。两名作者独立提取和分析数据。如有分歧，则通过阅读全文来解决。使用 Endnote X9 进行筛选和数据提取。使用 Review Manager 5.3 中的固定效应模型和随机效应模型对汇总数据进行分析。使用 Downs 和 Black 清单评估纳入研究的质量。
在回顾的 9863 篇文章中，有 23 篇文章被纳入荟萃分析。根据本研究的结果，子宫内膜异位症与妊娠期高血压（OR=1.11，95%CI：1.06，1.16；I²=45%，P<0.00001；N=8）、子痫前期（OR=1.26，95%CI：1.18，1.36；I²=37%，P<0.00001；N=12）和妊娠高血压疾病（OR=1.13，95%CI：1.06，1.21；I²=8%，P=0.0001；N=8）之间存在关联。
本研究证实子宫内膜异位症可能会增加妊娠高血压疾病的发病风险。提高对这一问题的认识将有助于确定妊娠高血压疾病的有效筛查和早期诊断策略。
