Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy, 16, Universitatii Street, 700115 Iasi, Romania.
Clinical Rehabilitation Hospital, 14, Pantelimon Halipa Street, 700661 Iasi, Romania.
Medicina (Kaunas). 2024 Jun 18;60(6):999. doi: 10.3390/medicina60060999.
: Coadministration of natural products to enhance the potency of conventional antirheumatic treatment is of high interest. This study aimed to assess the impact of administration of silymarin (a nutritional supplement) in patients with active rheumatoid arthritis under treatment with conventional disease-modifying antirheumatic drugs. : One-hundred and twenty-two patients diagnosed with active rheumatoid arthritis and treated with conventional disease-modifying antirheumatic drugs were randomly assigned to either control or intervention groups; the latter was supplemented with silymarin (300 mg/day) for 8 weeks. Indicators of disease activity, inflammatory markers, disease activity and disability indices, European League Against Rheumatism responses, fatigue, depression, and anxiety scores were determined at baseline and week 8. : Silymarin supplementation significantly reduced the number of tender and swollen joints, duration of morning stiffness, severity of pain, disease activity and disability indices, European League Against Rheumatism responses, levels of fatigue, depression, and anxiety. According to our results, silymarin substantially improved patients' general condition. : Our study provides evidence for the benefits of silymarin supplementation to disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis.
联合应用天然产物以增强常规抗风湿治疗的疗效具有重要意义。本研究旨在评估在接受常规疾病修饰抗风湿药物治疗的活动期类风湿关节炎患者中，应用水飞蓟素（一种营养补充剂）的效果。
122 名被诊断患有活动期类风湿关节炎且正在接受常规疾病修饰抗风湿药物治疗的患者被随机分配到对照组或干预组；后者接受水飞蓟素（300mg/天）治疗 8 周。在基线和第 8 周时测定疾病活动的指标、炎症标志物、疾病活动和残疾指数、欧洲抗风湿病联盟反应、疲劳、抑郁和焦虑评分。
水飞蓟素补充治疗显著降低了压痛关节和肿胀关节的数量、晨僵持续时间、疼痛严重程度、疾病活动和残疾指数、欧洲抗风湿病联盟反应、疲劳、抑郁和焦虑评分。根据我们的结果，水飞蓟素显著改善了患者的整体状况。
我们的研究为在活动期类风湿关节炎患者中，水飞蓟素补充治疗对疾病修饰抗风湿药物的益处提供了证据。
