Gauperaa T, Seljelid R
Acta Chir Scand. 1985;151(3):193-9.
Fibronectin is produced by several cell types, with hepatocytes currently recognized as the main source of plasma fibronectin. Mesenchymal cells produce fibronectin in vitro and probably do so even in vivo. But it is not clear if these cells represent the sole source of tissue fibronectin. In the present study, using direct and indirect immunofluorescence, fibronectin was found to occur ubiquitously in connective tissue in the rat. When 125I-labelled fibronectin was intravenously injected in rat, there was significant uptake of fibronectin in the tissues. The half-time for removal of labelled fibronectin in circulation was c. 15 hours. The authors conclude that flux of fibronectin occurs from plasma into the tissues and that in normal circumstances plasma fibronectin contributes to fibronectin in tissues.
纤连蛋白由多种细胞类型产生，目前认为肝细胞是血浆纤连蛋白的主要来源。间充质细胞在体外产生纤连蛋白，甚至在体内可能也会产生。但尚不清楚这些细胞是否是组织纤连蛋白的唯一来源。在本研究中，通过直接和间接免疫荧光法发现，纤连蛋白在大鼠的结缔组织中普遍存在。当给大鼠静脉注射125I标记的纤连蛋白时，组织中出现了对纤连蛋白的显著摄取。循环中标记纤连蛋白的清除半衰期约为15小时。作者得出结论，纤连蛋白从血浆流入组织，在正常情况下，血浆纤连蛋白有助于组织中的纤连蛋白。
