Dorfan Yuval, Nahami Avichay, Morris Yael, Shohat Benny, Kolodkin-Gal Ilana
Faculty of Electrical Engineering, Holon Institute of Technology, Holon 5810201, Israel.
The Scojen Institute for Synthetic Biology, Reichman University, Herzliya 4610101, Israel.
Microorganisms. 2024 Jun 18;12(6):1226. doi: 10.3390/microorganisms12061226.
The anti-fungal properties of the probiotic bacterium have been studied extensively in agriculture and ecology, but their applications in the built environment remain to be determined. Our work aims to utilize this biological component to introduce new diverse anti-mold properties into paint. "Mold" refers to the ubiquitous fungal species that generate visible multicellular filaments commonly found in household dust. The development of mold leads to severe health problems for occupants, including allergic response, hypersensitivity pneumonitis, and asthma, which have significant economic and clinical outcomes. We here demonstrate the robust effect of a commercial paint enhanced with Bacillus subtilis cells against the common mold agent, , and identify three biosynthetic clusters essential for this effect. Our results lay the foundation for bio-convergence and synthetic biology approaches to introduce renewable and environmentally friendly bio-anti-fungal agents into the built environment.
益生菌的抗真菌特性已在农业和生态学领域得到广泛研究,但其在建筑环境中的应用仍有待确定。我们的工作旨在利用这种生物成分,为涂料引入新的多样抗霉菌特性。“霉菌”指的是无处不在的真菌种类,其产生常见于家庭灰尘中的可见多细胞细丝。霉菌的生长会给居住者带来严重的健康问题,包括过敏反应、过敏性肺炎和哮喘,这些会产生重大的经济和临床后果。我们在此证明了添加枯草芽孢杆菌细胞的商用涂料对常见霉菌制剂的强大作用,并确定了产生这种作用所必需的三个生物合成簇。我们的研究结果为将可再生且环保的生物抗真菌剂引入建筑环境的生物融合和合成生物学方法奠定了基础。