Gutin B, Alejandro D, Duni T, Segal K, Phillips G B
Am J Med. 1985 Jul;79(1):79-84. doi: 10.1016/0002-9343(85)90549-2.
On the basis of previous findings, it has been hypothesized that hyperestrogenemia may be the major predisposing factor for coronary heart disease and that an elevation in the estradiol-to-testosterone ratio, or a closely related hormonal alteration, may cause the expression of risk factors for coronary heart disease. The present study was carried out to investigate whether exercise training, which has been reported to reduce risk factors for coronary heart disease, affects the serum sex hormone levels. The serum sex hormone levels, established risk factors for coronary heart disease, and physical fitness were measured in 10 men who had undergone at least six months of intensive exercise training and in 10 sedentary men of similar age. Despite evidence for a strikingly higher level of physical fitness and a lower level of risk factors in the trained group, no significant difference in mean serum estradiol level was found. Nor did three subjects from the sedentary group show a decrease in estradiol level after three to four months of exercise training. The mean estradiol-to-testosterone ratio, however, was significantly lower in the trained group and might account for the lower level of risk factors in that group. If the hypothesis is correct, exercise training may decrease established risk factors for coronary heart disease without decreasing the risk of coronary heart disease.
基于先前的研究结果，有人提出假设，高雌激素血症可能是冠心病的主要诱发因素，雌二醇与睾酮的比值升高，或与之密切相关的激素变化，可能导致冠心病危险因素的表达。本研究旨在调查据报道可降低冠心病危险因素的运动训练是否会影响血清性激素水平。对10名经过至少六个月强化运动训练的男性和10名年龄相仿的久坐不动男性，测量了血清性激素水平、已确定的冠心病危险因素和身体素质。尽管有证据表明训练组的身体素质明显更高，危险因素水平更低，但未发现平均血清雌二醇水平有显著差异。久坐组的三名受试者在进行三到四个月的运动训练后，雌二醇水平也没有下降。然而，训练组的平均雌二醇与睾酮比值显著较低，这可能是该组危险因素水平较低的原因。如果该假设正确，运动训练可能会降低已确定的冠心病危险因素，而不会降低冠心病风险。
